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FLASH GENE

Symbol

ANXA11

contributors: mct/npt - updated : 10-07-2018

HGNC name	annexin A11
HGNC id	535

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system uterus cervix   highly   female system breast mammary gland   highly   female system placenta     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a relatively long N terminus
	a C terminal "core" region made of four repeats homolog to the endonexin fold
	the calcium-dependent phospholipid binding sites

HOMOLOGY

interspecies	homolog to murine Anxa11
	homolog to C.elegans To7c4.9

Homologene

FAMILY

annexin family of calcium dependent phospholipid-binding proteins

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,granule
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
	intracellular,nucleus,nucleoplasm
	intracellular,nuclear envelope
text	cytoplasmic and possibly nuclear

basic FUNCTION	calcium and phospholipid binding protein
	playing an essential role in the terminal phase of cytokinesis
	has complex and essential functions in several biological pathways, including apoptosis and proliferation
	essential role for annexin 11 in the terminal phase of cytokinesis
	plays an important role in cell division, Ca(2+) signaling, vesicle trafficking and apoptosis
	ANXA11 maintains architectural and functional features of the ERES by coordinating with PDCD6 to stabilize SEC31A at the ER exit sites (ERES)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding, other,
	phospholipids
	Ca2+

protein	calcyclin associated
	PDCD6-binding partner (the N-terminal regulatory domain of ANXA11) and the PDCD6-binding domain of Alix/AIP1 are rich in Pro, Gly, Ala, Tyr and Gln)
	ANXA11, physically associates with SEC31A by the adaptor function of PDCD6

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ALS23

Susceptibility

to sarcoidosis

Variant & Polymorphism SNP	SNP (rs1049550, T > C, R230C) was found to be strongly associated with sarcoidosis

Candidate gene
Marker	is a promising biomarker for the diagnosis, treatment and prognosis of certain diseases
Therapy target

ANIMAL & CELL MODELS