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FLASH GENE
Symbol ANXA11 contributors: mct/npt - updated : 10-07-2018
HGNC name annexin A11
HGNC id 535
Corresponding disease
ALS23 amytrophic lateral sclerosis 23
Location 10q22.3      Physical location : 81.914.879 - 81.965.328
Synonym name
  • autoantigen 56k
  • calcyclin-associated annexin 50
  • annexin XI
    • Synonym symbol(s) ANX11, CAP-50, ALS23, CAP50
    DNA
    TYPE functioning gene
    STRUCTURE 51.72 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   long interspersed repetitive elements
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - initiation site 1958 - 505 - 2000 1101307
    exon 1a, 5'utr
    - initiation site 8534 - 505 - 2000 1101307
    exon 1a + 1c, 5'utr
    17 initiation site 2731 - 505 - 2000 1101307
  • exon 1a + 1b + 1c, 5'utr
  • ANXA11c
    • 17 - 2465 - 505 - 2000 1101307
    16 - 2535 - 505 - 2000 1101307
    15 - 2486 - 505 - 2000 1101307
    17 - 2804 - 472 - 2000 1101307
    17 - 3073 - 505 - 2000 1101307
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuteruscervix highly
     female systembreastmammary gland highly
     female systemplacenta  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a relatively long N terminus
  • a C terminal "core" region made of four repeats homolog to the endonexin fold
  • the calcium-dependent phospholipid binding sites
    • HOMOLOGY
    interspecies homolog to murine Anxa11
    homolog to C.elegans To7c4.9
    Homologene
    FAMILY
  • annexin family of calcium dependent phospholipid-binding proteins
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope
    text cytoplasmic and possibly nuclear
    basic FUNCTION
  • calcium and phospholipid binding protein
  • playing an essential role in the terminal phase of cytokinesis
  • has complex and essential functions in several biological pathways, including apoptosis and proliferation
  • essential role for annexin 11 in the terminal phase of cytokinesis
  • plays an important role in cell division, Ca(2+) signaling, vesicle trafficking and apoptosis
  • ANXA11 maintains architectural and functional features of the ERES by coordinating with PDCD6 to stabilize SEC31A at the ER exit sites (ERES)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • phospholipids
  • Ca2+
    • protein
  • calcyclin associated
  • PDCD6-binding partner (the N-terminal regulatory domain of ANXA11) and the PDCD6-binding domain of Alix/AIP1 are rich in Pro, Gly, Ala, Tyr and Gln)
  • ANXA11, physically associates with SEC31A by the adaptor function of PDCD6
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALS23
    Susceptibility to sarcoidosis
    Variant & Polymorphism SNP SNP (rs1049550, T > C, R230C) was found to be strongly associated with sarcoidosis
    Candidate gene
    Marker
  • is a promising biomarker for the diagnosis, treatment and prognosis of certain diseases
    • Therapy target
    ANIMAL & CELL MODELS