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FLASH GENE
Symbol PTPRN2 contributors: npt/mct - updated : 19-06-2018
HGNC name protein tyrosine phosphatase, receptor type, N polypeptide 2
HGNC id 9677
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional   deletion    
deletion of PTPRN, PTPRN2, structural proteins of secretory vesicles and modulators of neuroendocrine secretion, has a profound effect on the circadian system
Susceptibility to insulin dependent diabetes
Variant & Polymorphism
Candidate gene
Marker
  • with PTPRN are closely related proteins that were first identified as targets of autoantibodies in Type I diabetics (Caromile 2010)
  • PTPRN2 is a novel candidate biomarker in breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    therapeutic target in breast cancer (PMID: 25877877)
    ANIMAL & CELL MODELS