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FLASH GENE
Symbol PTPRN2 contributors: npt/mct - updated : 19-06-2018
HGNC name protein tyrosine phosphatase, receptor type, N polypeptide 2
HGNC id 9677
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracellular region
  • a single transmembrane region
  • a single intracellular catalytic domain
  • a tyrosine-protein phosphatase domain
  • HOMOLOGY
    interspecies homolog to murine IA2B/ICAR gene
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • receptor class 8 subfamily
  • CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text
  • in pancreatic beta cells, localized to the membrane of insulin-containing dense-core vesicles (Caromile 2010)
  • is localized at the membrane of secretory granules of pancreatic islet beta-cells
  • basic FUNCTION
  • implicated in development of nervous system and pancreatic endocrine cells
  • involved in insulin secretion in pancreatic beta-cells
  • PTPRN, PTPRN2 function is an essential regulator of autocrine insulin action in pancreatic beta-cells
  • with PTPRN, upregulate beta-cell transcription and proliferation (Suckale 2010)
  • functions as a phosphatidylinositol phosphatase that contributes to maintaining subcellular differences in levels of PIP that are important for regulating stimulus-coupled exocytosis of insulin (Caromile 2010)
  • plays a role in the regulation of insulin secretion, in ensuring proper granulogenesis and stability, and in the regulation of beta-cell growth
  • PTPRN, PTPRN2 are unique neuroendocrine-specific protein tyrosine phosphatases (PTPs)
  • expressed predominantly in endocrine and neuronal cells, where it functions in exocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is involved in beta-cell growth via regulating stability of IRS2 protein by the molecular interaction with insulin receptor
  • PTPRN2 and PLCB1 promote metastatic breast cancer cell migration through PI(4,5)P2-dependent actin remodeling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    deletion of PTPRN, PTPRN2, structural proteins of secretory vesicles and modulators of neuroendocrine secretion, has a profound effect on the circadian system
    Susceptibility to insulin dependent diabetes
    Variant & Polymorphism
    Candidate gene
    Marker
  • with PTPRN are closely related proteins that were first identified as targets of autoantibodies in Type I diabetics (Caromile 2010)
  • PTPRN2 is a novel candidate biomarker in breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    therapeutic target in breast cancer (PMID: 25877877)
    ANIMAL & CELL MODELS