basic FUNCTION
| implicated in development of nervous system and pancreatic endocrine cells |
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involved in insulin secretion in pancreatic beta-cells |
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PTPRN, PTPRN2 function is an essential regulator of autocrine insulin action in pancreatic beta-cells |
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with PTPRN, upregulate beta-cell transcription and proliferation (Suckale 2010) |
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functions as a phosphatidylinositol phosphatase that contributes to maintaining subcellular differences in levels of PIP that are important for regulating stimulus-coupled exocytosis of insulin (Caromile 2010) |
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plays a role in the regulation of insulin secretion, in ensuring proper granulogenesis and stability, and in the regulation of beta-cell growth |
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PTPRN, PTPRN2 are unique neuroendocrine-specific protein tyrosine phosphatases (PTPs) |
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expressed predominantly in endocrine and neuronal cells, where it functions in exocytosis |