Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

PLK1

contributors: mct - updated : 08-10-2022

HGNC name	polo-like kinase 1 (Drosophila)
HGNC id	9077

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in primary colorectal cancers and associated with p53 accumulation tumoral     --over   in infantile hepatoblastomas with poorer outcome tumoral       gain of function in esophageal cancer tumoral     --over   in bladder cancer (confers tumor progression advantages to urothelial cancer cells, although other factors are also involved) constitutional         induces DNA instability, which may be mediated by the accumulation of FBXO5, an inhibitor of APC/C, and geminin, an inhibitor of pre-prereplicative complex formation constitutional         increase MAVS activity, while its overexpression inhibited MAVS tumoral     --over   associated with shortened event-free survival and was an independent prognostic factor for non-Hodgkin lymphoma tumoral     --over   of PLK1 and KIF2C activities seen in cancer cells may account for a mechanism underlying the pathogenesis of genomic instability

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive liver with TP63, may be a candidate as a molecuar target of liver tumor treatments cancer hemopathy   new therapeutic target for non-Hodgkin lymphoma cancer     attractive target for the development of anticancer agents due to its importance in regulating cell-cycle progression cancer digestive   for therapeutic of hepatoblastoma, and esophageal cancer cancer reproductive prostate potential therapeutic strategy for advanced Prostate carcinoma therapy by co-targeting PLK1 and PELO miscelleaneous urinary chronic kidney disease targeting PLK1 could be a promising strategy for CKD treatment.

ANIMAL & CELL MODELS