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FLASH GENE
Symbol PLK1 contributors: mct - updated : 08-10-2018
HGNC name polo-like kinase 1 (Drosophila)
HGNC id 9077
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in primary colorectal cancers and associated with p53 accumulation
tumoral     --over  
in infantile hepatoblastomas with poorer outcome
tumoral       gain of function
in esophageal cancer
tumoral     --over  
in bladder cancer (confers tumor progression advantages to urothelial cancer cells, although other factors are also involved)
constitutional        
induces DNA instability, which may be mediated by the accumulation of FBXO5, an inhibitor of APC/C, and geminin, an inhibitor of pre-prereplicative complex formation
constitutional        
increase MAVS activity, while its overexpression inhibited MAVS
tumoral     --over  
associated with shortened event-free survival and was an independent prognostic factor for non-Hodgkin lymphoma
tumoral     --over  
of PLK1 and KIF2C activities seen in cancer cells may account for a mechanism underlying the pathogenesis of genomic instability
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerdigestiveliver
with TP63, may be a candidate as a molecuar target of liver tumor treatments
cancerhemopathy 
new therapeutic target for non-Hodgkin lymphoma
cancer  
attractive target for the development of anticancer agents due to its importance in regulating cell-cycle progression
cancerdigestive 
for therapeutic of hepatoblastoma, and esophageal cancer
ANIMAL & CELL MODELS