basic FUNCTION
| postsynaptic GRID2 is a key regulator of the presynaptic active zone and postsynaptic density organization at parallel fiber-Purkinje cell synapses in the adult brain  |
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presence of GRID2 plays an important role in controlling cerebellar functioning  |
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excitatory neurotransmitter receptors playing an important role in cerebellar long-term depression, motor learning, motor coordination and synapse development |
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BCL2L2 and GRID2 are two critical proteins acting in distinct pathways to regulate mitochondrial morphogenesis and control Purkinje cell dendrite development and synapse formation  |
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differently regulates parallel fiber synaptogenesis and cerebellar long-term depression (LTD) through the extracellular N-terminal domain and the cytoplasmic C-terminal end, respectively  |
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essential for cerebellar synapse formation  |
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potentially mediates cerebellar synapse formation by interacting with presynaptic NRXNs through CBLN1  |
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is part of the GRM11 signaling complex needed for cerebellar synaptic function and motor coordination  |
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novel functional role of GRID2 in the retina  |
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possible role for GRID2 as possible phenotype modifier in MVKD patients, especially in those with severe phenotypes  |
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can be a suppressor in TNF-induced neurodegeneration which may help to understand the main factors leading to autism  |