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FLASH GENE

Symbol

DNMT1

contributors: shn/mct - updated : 22-12-2016

HGNC name	DNA (cytosine-5-)-methyltransferase 1
HGNC id	2976

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Dnmt1 mutant mice with 90% of hypomethylated cortical and hippocampal cells in the dorsal forebrain from E13.5 on are viable but display severe neuronal cell death between E14.5
	conditional mutant mice lacking Dnmt1 and Dnmt3 in forebrain excitatory neurons have abnormal long-term plasticity in the hippocampal CA1 region with deficits in learning and memory