basic FUNCTION
| endolysosomal aspartic proteinase predominantly expressed in cells of the immune system, having an important role in immune responses |
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major intracellular aspartic protease which is predominantly present in the cells of immune system and is frequently implicated in antigen processing via the MHC class II pathway |
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may play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain |
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playing an important role for preventing the accumulation of the lysosomal membrane sialoglycoproteins |
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playing an important role for exogenous antigen processing via the major histocompatibility complex class II presenting system |
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specifically induces tumor growth arrest and apoptosis in prostate carcinoma cell lines without affecting normal cells (Zaidi 2008) |
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important in the processing of tetanus toxin C-fragment in primary B cells |