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FLASH GENE

Symbol

GFRA1

contributors: mct/npt - updated : 07-06-2008

HGNC name	GDNF family receptor alpha 1
HGNC id	4243

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 2919 51 465 - Esseghir (2007) variant 2 - - 2592 - 460 - Esseghir (2007)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine       Endocrine parathyroid       highly Reproductive female system breast mammary gland   highly

cells

System Cell Pubmed Species Stage Rna symbol digestif intestine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four cysteine residues linked by hinge regions

secondary structure

nine alpha helices with two central beta strands

conjugated

GlycoP

HOMOLOGY

intraspecies

homolog to GFRA2,GFRA3,GFRA4

Homologene

FAMILY

GDNFR family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	anchored to the membrane by a C terminal glycosyl phosphatidylinositol (GPI)-linkage

basic FUNCTION	glycosylphosphatidylinositol-anchored cell surface coreceptor for GDNF, involved in RET signaling pathway
	receptor for neurturin
	mediating the action of Ret protein receptor tyrosine kinase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	GDNF
	NTRN

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in a subset of estrogen receptor-positive breast tumors

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS