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FLASH GENE
Symbol CTRB1 contributors: mct - updated : 09-11-2021
HGNC name chymotrypsinogen B1
HGNC id 2521
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Lymphoid/Immunespleen    
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion duodenal juice
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains a peptidase s1 domain
isoforms Precursor
HOMOLOGY
intraspecies homolog to trypsinogen
Homologene
FAMILY peptidase s1 family, serine protease chymotrypsin family
CATEGORY enzyme , secretory
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • serine protease, cleaving preferentially Tyr after an aromatic residue
  • playing a key role in the enteroendocrine system (
  • involved in the regulation of the incretin pathway, development of diabetes, and response to DPP-4 inhibitor treatment (
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion
    text proteolysis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to age-related macular degeneration (AMD)
    • Variant & Polymorphism other
  • strong protective signal for a common variant (rs8056814) near CTRB1 associated with a decrease in AMD risk
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS