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FLASH GENE

Symbol

CTRB1

contributors: mct - updated : 09-11-2021

HGNC name	chymotrypsinogen B1
HGNC id	2521

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	5.94 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001906 7 - 870 NP_001897 - 263 - 2020 33036922 NM_001329190 6 - 736 NP_001316119 - 233 - 2020 33036922

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Lymphoid/Immune spleen         Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage
cell lines
fluid/secretion	duodenal juice

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a peptidase s1 domain

isoforms

Precursor

HOMOLOGY

intraspecies

homolog to trypsinogen

Homologene

FAMILY

peptidase s1 family, serine protease chymotrypsin family

CATEGORY

enzyme , secretory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	serine protease, cleaving preferentially Tyr after an aromatic residue
	playing a key role in the enteroendocrine system (
	involved in the regulation of the incretin pathway, development of diabetes, and response to DPP-4 inhibitor treatment (

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

digestion

text	proteolysis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to age-related macular degeneration (AMD)

Variant & Polymorphism other	strong protective signal for a common variant (rs8056814) near CTRB1 associated with a decrease in AMD risk

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS