| Symbol
| THBS4
| contributors: mct - updated : 21-03-2021
|
| HGNC name
| thrombospondin 4
|
| HGNC id
| 11788
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --low
|
|
by increased methylation in colorectal cancer ( | | tumoral
|
|
| --over
|
| |
in hepatocellular carcinoma patients, high THBS4 expression was associated with shorter overall and disease-free survival compared with low THBS4 expression | |
| Susceptibility
|
myocardial infarction |
| Variant & Polymorphism
SNP
| A387P significantly associated to myocardial infarction |
| 
|
Candidate gene
| Marker
| its level may be a biomarker for the occurrence of colorectal adenomas and carcinoma | |
powerful marker for diffuse-type gastric adenocarcinomas and to provide an initial characterization of its expression in the course of this disease | |
may be an endothelial specific marker of cardiac overload | |
may be an independent prognostic marker for hepatocellular carcinoma patients | Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | digestive | liver | |
| potential therapeutic target for hepatocellular carcinoma patients | | neuromuscular | myopathy | | |
| is a potential therapeutic target for muscular dystrophy | | miscelleaneous | pain | | |
| Controlling TSP4 overexpression in peripheral sensory neurons may be a target for analgesic drug development for neuropathic pain |
| | |
|
| in mice lacking TSP4 (Tsp4& | |
8315;-/-), hearts failed to acutely augment contractility or activate stretch-response pathways (ERK1/2 and Akt) on exposure to acute pressure overload |