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FLASH GENE

Symbol

CTH

contributors: mct - updated : 03-07-2018

HGNC name	cystathionase (cystathionine gamma-lyase)
HGNC id	2501

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CTHD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   stimulates smooth muscle cells apoptosis due to an increased endogenous production of H2S constitutional   deletion     CTH gene deletion exacerbated mitochondrial fragmentation and apoptosis of renal tubule cells after unilateral ureteral obstruction (UUO)

Susceptibility

to atherosclerosis

Variant & Polymorphism SNP	1364T/T associated with higher homocysteine concentration and risk of atherosclerosis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS