| basic FUNCTION
| involved in the final step in the trans-sulfuration pathway synthesizing L-cysteine from L-methionine |
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key enzyme in the trans-sulfuration pathway, which uses L-cysteine to produce hydrogen sulfide (H2S)  |
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critical for cysteine biosynthesis through the transsulfuration pathway and the combination of CTH deficiency and lack of dietary cysteine supply would threaten life sustainability |
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one of the major enzymes for the production of hydrogen sulphide (H(2)S), a multifunctional gasotransmitter in the pancreatic beta-cell |
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although CTH is responsible for the H2S production in the heart, CTH proteins are undetectable in cardiomyocytes or heart tissues |
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protects likely against renal ischemia/reperfusion injury, likely by modulating oxidative stress through the production of H2S |
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is a key enzyme in the trans-sulfuration pathway responsible for the production of endogenous H2S |
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CBS and CTH are critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex |
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is one major H2S-producing enzyme with L-cysteine as the main substrate in mammalian cells |
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the l-cysteine/CTH/H2 S pathway is involved in melanoma progression. |
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key role for the H2S-generating enzymes CBS and CTH in pulmonary vascular development and homeostasis and in lung alveolarization |
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is expressed in human atherosclerotic plaque microvessels and is involved in micro-angiogenesis |
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last key enzyme of the transsulfuration pathway, involved in the production of hydrogen sulfide (H2S) and glutathione (GSH), which regulate redox balance and act as important antioxidant molecules |
