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FLASH GENE

Symbol

PIK3CD

contributors: mct - updated : 31-08-2017

HGNC name	phosphoinositide-3-kinase, catalytic, delta polypeptide
HGNC id	8977

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IMD14

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function       --over   in blast cells from acute myeloid leukemia constitutional       loss of function in macrophages led to reduced AKT1 and RAC1 activation, but paradoxically to increased RHOA and PTEN activity

Susceptibility

to primary B-cell immunodeficiency

Variant & Polymorphism other	mutated in primary B-cell immunodeficiency

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   could be druggable in the therapy of diffuse large B cell lymphoma cancer hemopathy   potential therapeutic target in acute myeloid leukemia immunology inflammatory   PI3Kδ inhibition could be chondroprotective in rheumatoid arthritis (RA) by modulating synoviocyte growth, migration, and invasion

ANIMAL & CELL MODELS