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FLASH GENE
Symbol PIK3CD contributors: mct - updated : 31-08-2017
HGNC name phosphoinositide-3-kinase, catalytic, delta polypeptide
HGNC id 8977
ASSOCIATED DISORDERS
corresponding disease(s) IMD14
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
      --over  
in blast cells from acute myeloid leukemia
constitutional       loss of function
in macrophages led to reduced AKT1 and RAC1 activation, but paradoxically to increased RHOA and PTEN activity
Susceptibility to primary B-cell immunodeficiency
Variant & Polymorphism other mutated in primary B-cell immunodeficiency
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerhemopathy 
could be druggable in the therapy of diffuse large B cell lymphoma
cancerhemopathy 
potential therapeutic target in acute myeloid leukemia
immunologyinflammatory 
PI3Kδ inhibition could be chondroprotective in rheumatoid arthritis (RA) by modulating synoviocyte growth, migration, and invasion
ANIMAL & CELL MODELS