Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZBTB24 contributors: mct - updated : 09-01-2019
HGNC name zinc finger and BTB domain containing 24
HGNC id 21143
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a BTB/POZ domain
    • HOMOLOGY
    interspecies ortholog to murine Zbtb24
    Homologene
    FAMILY kruppel family of C2H2-type zinc-finger proteins
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the regulation of transcription, DNA-dependent
  • ZBTB24, HELLS, CDCA7 gene products are not involved in establishing or maintaining subtelomeric methylation
  • potential role as a transcriptional regulator that is not restricted to immune cells
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • ZBTB24 can likely function as a transcription factor directly controlling CDCA7 expression
  • ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation
  • MN1 participates in transcriptional regulation of target genes through interaction with the transcription factors PBX1, PKNOX1, and ZBTB24
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICF2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS