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FLASH GENE
Symbol ZBTB24 contributors: mct - updated : 09-01-2019
HGNC name zinc finger and BTB domain containing 24
HGNC id 21143
DNA
TYPE functioning gene
STRUCTURE 20.72 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 5597 - 697 - -
2 - 1260 - 333 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systembreastmammary gland  
 female systemuteruscervix  
 male systemprostate   
Urinarybladder    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a BTB/POZ domain
  • HOMOLOGY
    interspecies ortholog to murine Zbtb24
    Homologene
    FAMILY kruppel family of C2H2-type zinc-finger proteins
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the regulation of transcription, DNA-dependent
  • ZBTB24, HELLS, CDCA7 gene products are not involved in establishing or maintaining subtelomeric methylation
  • potential role as a transcriptional regulator that is not restricted to immune cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • ZBTB24 can likely function as a transcription factor directly controlling CDCA7 expression
  • ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation
  • MN1 participates in transcriptional regulation of target genes through interaction with the transcription factors PBX1, PKNOX1, and ZBTB24
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICF2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS