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FLASH GENE

Symbol

ZBTB24

contributors: mct - updated : 09-01-2019

HGNC name	zinc finger and BTB domain containing 24
HGNC id	21143

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014797 7 - 5597 NP_055612 - 697 - - NM_001164313 2 - 1260 NP_001157785 - 333 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system breast mammary gland       female system uterus cervix       male system prostate       Urinary bladder

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a BTB/POZ domain

HOMOLOGY

interspecies

ortholog to murine Zbtb24

Homologene

FAMILY

kruppel family of C2H2-type zinc-finger proteins

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	involved in the regulation of transcription, DNA-dependent
	ZBTB24, HELLS, CDCA7 gene products are not involved in establishing or maintaining subtelomeric methylation
	potential role as a transcriptional regulator that is not restricted to immune cells

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein	ZBTB24 can likely function as a transcription factor directly controlling CDCA7 expression
	ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation
	MN1 participates in transcriptional regulation of target genes through interaction with the transcription factors PBX1, PKNOX1, and ZBTB24

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ICF2

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS