| basic FUNCTION
| involved in cytoskeletal organization by sequestering actin monomers |
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both a SHH-responsive gene and a new member of the pathway that modulates GLI responses during growth and tumorigenesis  |
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prognostic indicator of disease-free survival in breast cancer patients and demonstrates the ability to play a role in governing the metastatic nature of breast cancer cells |
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required at the basal body of mesenchymal cells for cilia maintenance, SHH responsiveness, and de novo hair follicle formation |
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promotes ciliogenesis by antagonizing Src-dependent phosphorylation of Cortactin |
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involved in the Shh signaling pathway in the developing hair follicle and in basal cell carcinomas of the skin |
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acts as a scaffold protein that interacts with multiple partners to regulate actin dynamics |
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may act as a scaffold protein to activate actin assembly |
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tissue-specific regulator of plasma membrane dynamics, whose altered expression levels have been linked to cancer metastasis |
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modulates interplay between the actin cytoskeleton and plasma membrane to promote the maintenance of intercellular contacts in kidney epithelia |
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required for neural fold elevation and apical constriction along with cell polarization and elongation in both the superficial and deep layers of the anterior neural plate |
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function as a cytoskeletal protein with a role in cancer metastasis |
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exerted tumor suppressor effects and arrested cells in the G2/M phase, but not the G1/S phase of the cell cycle when it was depleted or overexpressed in hepatocellular carcinoma (HCC) cells |
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enhances the localization of the epidermal growth factor receptor (EGFR) to the plasma membrane |
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MTSS1 positively modulates EGF signaling at low cell densities to promote proliferation and, therefore, may be beneficial for the early stages of primary head and neck squamous carcinoma cells tumor growth |
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promotes the ability of melanocytic cells to metastasize and engages actin dynamics via Rho-GTPases and cofilin in this process |
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might have a context-dependent function and could act as a tumor suppressor, which is pharmacologically targetable in Acute Myeloid Leukemia patients |
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nucleator of dendritic spines, accumulated to future spine initiation sites in a PIP2-dependent manner and deformed the plasma membrane outward into a proto-protrusion |
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acts as oncogene and pro-migratory factor in melanoma tumors |
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MTSS2, MTSS1, BAIAP2 promote negative, concave curvature based on their ability to self-associate, having distinct functions in synapse formation and synaptic plasticity |
