motifs/domains
| a N terminal CARD (caspase recruitment domain), CARD-NOD domain, directly interacting with the NOD domains of NAIP  |
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twelve WD repeats (an insertion of 11 repeats between the CARD |
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ATPase domains and another 43AA insertion creating an additional WD-40 repeat) |
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a poly Ser domain (95-98 AA) and a NB-ARC domain (AA 93 to 403) |
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a CED4 domain involved in interaction with UTP6 , and that directly binds to the central domain of NUP107 in an ATR-regulated, phosphorylation-dependent manner |
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a central nucleotide-binding oligomerization domain |
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multiple WD40 domain repeats at the C-terminus that bind to Cytochrome C |
| basic FUNCTION
| functions as an adaptor in an 700-kDa multiprotein complex (named the apoptosome) to mediate the activation of caspase-9 |
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activating apoptosis caspase 9 and APF1 complex apoptosome in presence of cytopchrome C and ATP-leading to activation of caspase 3 and so to apoptosis |
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induced NF kappaB and NICK signaling molecules |
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hemoglobin scavenger receptor |
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might have a hitherto unsuspected role in the maintenance of genomic stability and cell cycle arrest, independent from its function in the apoptosis machinery |
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caspase-activating complex, APAF1 plays a central role in the mitochondrial caspase activation pathway of apoptosis |
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essential factor for cytochrome c-driven caspase activation during mitochondrial apoptosis but has also an apoptosis-unrelated function |
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implication in DNA damage-induced cell-cycle arrest (exerts two distinct, phylogenetically conserved roles in response to mitochondrial membrane permeabilization and DNA damage) |
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involvement in melanoma progression and chemoresistance |
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playing a necessary role for the cleavage or activation of all procaspases and the promotion of mitochondrial apoptotic events induced by genotoxic drugs |
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essential component of the apoptosome, the molecular complex assembled in response to mitochondrial cytochrome c release that promotes caspase activation |
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role in the maintenance of genomic stability, independently from its function in the cell death machinery |
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does not require energy from nucleotide hydrolysis to eventually form the apoptosome |
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key regulator gene of apoptosis, located downstream from TP53 |
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having a non-apoptosis-related role in the pathology of protein-aggregation-dependent neurodegenerative diseases such as Huntington disease |
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required for minocycline-dependent inhibition of cell death |
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might potentially serve as a direct or indirect sensor or modulator of ER/mitochondria metabolic condition |
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relays the death signal in the mitochondrial pathway of apoptosis |
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main component of the apoptosome, and a crucial factor in the mitochondria-dependent death pathway |
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acts by regulating the recruitment of UTP6, with which it interacts, to the centrosome |
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might also be considered a pro-survival molecule, whose absence impairs cell performance and causes a higher responsiveness to stressful conditions |
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involved in the DNA damage response through cell-cycle arrest induced by genotoxic stress |
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crucial role of APAF1 nuclear relocalization in mediating cell-cycle arrest induced by genotoxic stress |
