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FLASH GENE
Symbol APAF1 contributors: mct/npt/pgu - updated : 05-06-2015
HGNC name apoptotic peptidase activating factor 1
HGNC id 576
ANIMAL & CELL MODELS
  • murine Apaf1 null die at E16.5 day with craniofacial malformation, brain overgrowth, lens and retina alteration but persistence of interdigital webs and reduced apoptosis in fibroblasts
  • a Drosophila model of Huntington disease shows that inactivation of the dark gene (Drosophila Apaf-1 related killer) suppresses the formation of polyQ aggregates and diminishes the associated pathogenesis