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FLASH GENE
Symbol SNAI2 contributors: mct - updated : 15-02-2017
HGNC name snail homolog 2 (Drosophila)
HGNC id 11094
ASSOCIATED DISORDERS
corresponding disease(s) PBT2 , WS2D
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation      
in sporadic neural tube defects
tumoral     --over  
in colon cancer with invasive phenotype
tumoral     --over  
in mesenchymal tumours
constitutional     --low  
highly and transitory up-regulated during the partial-epithelial-mesenchymal transition EMT phase of tubulogenesis
tumoral     --over  
increased glioblastoma cell proliferation and invasion and promoted angiogenesis and glioblastoma growth
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
obesity  
may lead to the development of targeted drugs for the treatment of patients with obesity and/or lipodystrophy
metabolismlipid 
cancerhemopathy 
therapeutic benefits for patients after clinical myelosuppressive treatment
ANIMAL & CELL MODELS