| 1 | IMP3, SNAI2, TAZ, WNT5B
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| IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer.
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| Samanta S, Guru S, Elaimy AL, Amante JJ, Ou J, Yu J, Zhu LJ, Mercurio AM.
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| Cell Rep 23(9):2559-2567. doi: 10.1016/j.celrep.2018.04.113.
2018
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| 2 | PKNOX1, SNAI2
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| Prep1 (pKnox1) transcription factor contributes to pubertal mammary gland branching morphogenesis.
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| Sicouri L, Pisati F, Pece S, Blasi F, Longobardi E.
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| Int J Dev Biol 62(11-12):827-836. doi: 10.1387/ijdb.180278fb.
2018
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| 3 | SNAI2, STAMBP
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| STAM-binding protein regulates melanoma metastasis through SLUG stabilization.
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| Iwakami Y, Yokoyama S, Watanabe K, Hayakawa Y.
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| Biochem Biophys Res Commun. Dec 9;507(1-4):484-488. doi: 10.1016/j.bbrc.2018.11.068. Epub 2018 Nov 16. 2018
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| 4 | POU2F1, SNAI1, SNAI2, TWIST1, ZEB1
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| POU2F1 over-expression correlates with poor prognoses and promotes cell growth and epithelial-to-mesenchymal transition in hepatocellular carcinoma.
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| Zhong Y, Huang H, Chen M, Huang J, Wu Q, Yan GR, Chen.
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| Oncotarget 8(27):44082-44095. doi: 10.18632/oncotarget.17296. 2017
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| 5 | SNAI2, TWIST1, ZHX1
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| Roles of zinc-fingers and homeoboxes 1 during the proliferation, migration, and invasion of glioblastoma cells.
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| Kwon RJ, Han ME, Kim YJ, Kim YH, Kim JY, Liu L, Heo W, Oh SO.
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| Tumour Biol. Mar;39(3):1010428317694575. doi: 10.1177/1010428317694575 2017
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| 6 | SNAI1, SNAI2, VANGL1, ZEB1, ZEB2
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| KITENIN promotes glioma invasiveness and progression, associated with the induction of EMT and stemness markers.
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| Lee KH, Ahn EJ, Oh SJ, Kim O, Joo YE, Bae JA, Yoon S, Ryu HH, Jung S, Kim KK, Lee JH, Moon KS.
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| Oncotarget 6(5):3240-53.
2015
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| 7 | AURKA, BRCA2, FBN1, SNAI2
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| Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis.
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| Wang Z, Liu Y, Lu L, Yang L, Yin S, Wang Y, Qi Z, Meng J, Zang R, Yang G.
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| Oncotarget 6(9):6670-83.
2015
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| 8 | NANOG, SNAI1, SNAI2
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| A genome-wide RNAi screen identifies opposing functions of Snai1 and Snai2 on the Nanog dependency in reprogramming.
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| Gingold JA, Fidalgo M, Guallar D, Lau Z, Sun Z, Zhou H, Faiola F, Huang X, Lee DF, Waghray A, Schaniel C, Felsenfeld DP, Lemischka IR, Wang J.
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| Mol Cell 56(1):140-52. doi: 10.1016/j.molcel.2014.08.014. Epub 2014 Sep 15.
2014
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| 9 | HMGA2, SNAI2
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| HMGA2 induces transcription factor Slug expression to promote epithelial-to-mesenchymal transition and contributes to colon cancer progression.
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| Li Y, Zhao Z, Xu C, Zhou Z, Zhu Z, You T.
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| Cancer Lett 355(1):130-40. doi: 10.1016/j.canlet.2014.09.007. Epub 2014 Sep 11.
2014
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| 10 | SNAI1, SNAI2
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| DNA methylation is associated with transcription of Snail and Slug genes.
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| Chen Y, Wang K, Qian CN, Leach R.
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| Biochem Biophys Res Commun 430(3):1083-90. doi: 10.1016/j.bbrc.2012.12.034. Epub 2012 Dec 19.
2013
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| 11 | SNAI2, SOX9
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| Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling.
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| Liu JA, Wu MH, Yan CH, Chau BK, So H, Ng A, Chan A, Cheah KS, Briscoe J, Cheung M.
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| Proc Natl Acad Sci U S A 110(8):2882-7. doi: 10.1073/pnas.1211747110. Epub 2013 Feb 4.
2013
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| 12 | SNAI2, SOX9
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| Slug and Sox9 cooperatively determine the mammary stem cell state.
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| Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, Itzkovitz S, Noske A, Zürrer-Härdi U, Bell G, Tam WL, Mani SA, van Oudenaarden A, Weinberg RA.
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| Cell 148(5):1015-28. doi: 10.1016/j.cell.2012.02.008.
2012
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| 13 | KLF4, SNAI2
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| Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor β-initiated prostate cancer epithelial-mesenchymal transition.
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| Liu YN, Abou-Kheir W, Yin JJ, Fang L, Hynes P, Casey O, Hu D, Wan Y, Seng V, Sheppard-Tillman H, Martin P, Kelly K.
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| Mol Cell Biol 32(5):941-53. doi: 10.1128/MCB.06306-11. Epub 2011 Dec 27.
2012
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| 14 | PRDX1, SNAI1, SNAI2
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| Human peroxiredoxin 1 modulates TGF-β1-induced epithelial-mesenchymal transition through its peroxidase activity.
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| Ha B, Kim EK, Kim JH, Lee HN, Lee KO, Lee SY, Jang HH.
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| Biochem Biophys Res Commun 421(1):33-7. doi: 10.1016/j.bbrc.2012.03.103. Epub 2012 Mar 27.
2012
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| 15 | CDH6, PHF12, SIN3A, SNAI2
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| A PHD12-Snail2 repressive complex epigenetically mediates neural crest epithelial-to-mesenchymal transition.
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| Strobl-Mazzulla PH, Bronner ME.
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| J Cell Biol 198(6):999-1010. doi: 10.1083/jcb.201203098.
2012
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| 16 | SNAI2, TWIST1
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| Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis.
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| Casas E, Kim J, Bendesky A, Ohno-Machado L, Wolfe CJ, Yang J.
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| Cancer Res 71(1):245-54.
2011
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| 17 | CCND1, SNAI2, UBE2D3
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| SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination.
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| Mittal MK, Singh K, Misra S, Chaudhuri G.
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| J Biol Chem 286(1):469-79. Epub 2010 Nov 2.
2011
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| 18 | CXCL12, SNAI2
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| Slug contributes to the regulation of CXCL12 expression in human osteoblasts.
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| Piva R, Manferdini C, Lambertini E, Torreggiani E, Penolazzi L, Gambari R, Pastore A, Pelucchi S, Gabusi E, Piacentini A, Filardo G, Facchini A, Lisignoli G.
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| Exp Cell Res 317(8):1159-68. Epub 2010 Dec 21.
2011
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| 19 | SNAI1, SNAI2, TCF3
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| Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis.
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| Lee K, Gjorevski N, Boghaert E, Radisky DC, Nelson CM.
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| EMBO J 30(13):2662-74. doi: 10.1038/emboj.2011.159.
2011
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| 20 | SNAI2
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| Snail2 controls mesodermal BMP/Wnt induction of neural crest.
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| Shi J, Severson C, Yang J, Wedlich D, Klymkowsky MW.
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| Development 138(15):3135-45. Epub 2011 Jun 29.
2011
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| 21 | SNAI2, ZEB1
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| Transcriptional activation of ZEB1 by Slug leads to cooperative regulation of the epithelial-mesenchymal transition-like phenotype in melanoma.
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| Wels C, Joshi S, Koefinger P, Bergler H, Schaider H.
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| J Invest Dermatol 131(9):1877-85. doi: 10.1038/jid.2011.142. Epub 2011 May 19.
2011
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| 22 | MYB, SNAI2
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| Expression of Slug is regulated by c-Myb and is required for invasion and bone marrow homing of cancer cells of different origin.
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| Tanno B, Sesti F, Cesi V, Bossi G, Ferrari-Amorotti G, Bussolari R, Tirindelli D, Calabretta B, Raschellà G.
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| J Biol Chem 285(38):29434-45. Epub 2010 Jul 11.
2010
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| 23 | SNAI2
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| SNAI2/Slug promotes growth and invasion in human gliomas.
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| Yang HW, Menon LG, Black PM, Carroll RS, Johnson MD.
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| BMC Cancer 10:301.
2010
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| 24 | SNAI2
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| Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration.
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| Sun Y, Shao L, Bai H, Wang ZZ, Wu WS.
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| Blood 115(9):1709-17. Epub 2009 Dec 23.
2010
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| 25 | SNAI2
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| Slug gene expression supports human osteoblast maturation.
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| Lambertini E, Lisignoli G, Torreggiani E, Manferdini C, Gabusi E, Franceschetti T, Penolazzi L, Gambari R, Facchini A, Piva R.
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| Cell Mol Life Sci 66(22):3641-53. Epub 2009 Sep 11.
2009
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| 26 | SNAI2
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| Cutaneous wound reepithelialization is compromised in mice lacking functional Slug (Snai2).
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| Hudson LG, Newkirk KM, Chandler HL, Choi C, Fossey SL, Parent AE, Kusewitt DF.
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| J Dermatol Sci 56(1):19-26. Epub 2009 Jul 29.
2009
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| 27 | MMP17, SNAI2
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| Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis.
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| Huang CH, Yang WH, Chang SY, Tai SK, Tzeng CH, Kao JY, Wu KJ, Yang MH.
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| Neoplasia 11(12):1371-82.
2009
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| 28 | SNAI2
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| Switching in discoid domain receptor expressions in SLUG-induced epithelial-mesenchymal transition.
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| Maeyama M, Koga H, Selvendiran K, Yanagimoto C, Hanada S, Taniguchi E, Kawaguchi T, Harada M, Ueno T, Sata M.
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| Cancer 113(10):2823-31.
2008
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| 29 | SNAI1, SNAI2
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| Slug is a direct Notch target required for initiation of cardiac cushion cellularization.
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| Niessen K, Fu Y, Chang L, Hoodless PA, McFadden D, Karsan A.
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| J Cell Biol 182(2):315-25.
2008
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| 30 | SNAI2, SNAI3, SCRT1, SCRT2, CTBP1
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| Human SLUG does not directly bind to CtBP1.
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| Bailey CK, Misra S, Mittal MK, Chaudhuri G.
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| Biochem Biophys Res Commun 353(3):661-4. Epub 2006 Dec 22. 2007
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| 31 | SNAI2
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| Adipose tissue mass is modulated by SLUG (SNAI2).
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| PŽrez-Mancera PA, Bermejo-Rodr’guez C, Gonz‡lez-Herrero I, Herranz M, Flores T, JimŽnez R, S‡nchez-Garc’a I.
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| Hum Mol Genet 16(23):2972-86. Epub 2007 Sep 28. 2007
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| 32 | CDH6, SNAI2
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| Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest.
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| Taneyhill LA, Coles EG, Bronner-Fraser M.
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| Development 134(8):1481-90. Epub 2007 Mar 7.
2007
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| 33 | SNAI1, SNAI2
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| Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesis.
|
| Leroy P, Mostov KE.
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| Mol Biol Cell 18(5):1943-52. Epub 2007 Mar 7.
2007
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| 34 | SLC6A2, SNAI2, SCRT1, SCRT2
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| A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder.
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| Kim CH, Hahn MK, Joung Y, Anderson SL, Steele AH, Mazei-Robinson MS, Gizer I, Teicher MH, Cohen BM, Robertson D, Waldman ID, Blakely RD, Kim KS.
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| Proc Natl Acad Sci U S A 103(50):19164-9. Epub 2006 Dec 4. 2006
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| 35 | PRSS8, SNAI2
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| Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG.
|
| Chen M, Chen LM, Chai KX.
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| Prostate 66(9):911-20. 2006
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| 36 | AHR, SNAI2
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| Zinc finger transcription factor Slug is a novel target gene of aryl hydrocarbon receptor.
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| Ikuta T, Kawajiri K.
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| Exp Cell Res 312(18):3585-94. Epub 2006 Aug 9. 2006
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| 37 | SNAI2
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| Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma.
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| Wu WS, Heinrichs S, Xu D, Garrison SP, Zambetti GP, Adams JM, Look AT.
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| Cell 123(4):641-53. 2005
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| 38 | SNAI2
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| Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells.
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| Tripathi MK, Misra S, Khedkar SV, Hamilton N, Irvin-Wilson C, Sharan C, Sealy L, Chaudhuri G.
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| J Biol Chem 280(17):17163-71. Epub 2005 Feb 24. 2005
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| 39 | SNAI2
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| SLUG in cancer development.
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| Perez-Mancera PA, Gonzalez-Herrero I, Perez-Caro M, Gutierrez-Cianca N, Flores T, Gutierrez-Adan A, Pintado B, Sanchez-Martin M, Sanchez-Garcia I.
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| Oncogene 24(19):3073-82. 2005
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| 40 | SNAI2, VDR
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| The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer.
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| Palmer HG, Larriba MJ, Garcia JM, Ordonez-Moran P, Pena C, Peiro S, Puig I, Rodriguez R, De La Fuente R, Bernad A, Pollan M, Bonilla F, Gamallo C, De Herreros AG, Munoz A.
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| Nat Med 10(9):917-9. Epub 2004 Aug 22. 2004
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| 41 | PBT2, SNAI2
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| Deletion of the SLUG (SNAI2) gene results in human piebaldism.
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| Sanchez-Martin M, Perez-Losada J, Rodriguez-Garcia A, Gonzalez-Sanchez B, Korf BR, Kuster W, Moss C, Spritz RA, Sanchez-Garcia I.
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| Am J Med Genet 122A(2):125-32. 2003
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| 42 | SNAI2, WS2D
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| SLUG (SNAI2) deletions in patients with Waardenburg disease.
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| Sanchez-Martin M, Rodriguez-Garcia A, Perez-Losada J, Sagrera A, Read AP, Sanchez-Garcia I.
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| Hum Mol Genet 11(25):3231-6. 2002
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| 43 | SNAI2
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| The SLUG zinc-finger protein represses E-cadherin in breast cancer.
|
| Hajra KM, Chen DY, Fearon ER.
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| Cancer Res 62(6):1613-8. 2002
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| 44 | SNAI2, SNAI1
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| Identification and analysis of two snail genes in the pufferfish (Fugu rubripes) and mapping of human SNA to 20q.
|
| Smith S, Metcalfe JA, Elgar G.
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| Gene 247(1-2):119-28. 2000
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| 45 | SNAI2
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| SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein.
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| Inukai T, Inoue A, Kurosawa H, Goi K, Shinjyo T, Ozawa K, Mao M, Inaba T, Look AT.
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| Mol Cell 4(3):343-52 1999
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| 46 | SNAI2
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| Human SLUG gene organization, expression, and chromosome map location on 8q.
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| Cohen ME, et al.
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| Genomics 51 : 468-471. 1998
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| 47 | SNAI2
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| Localization of a neural crest transcription factor, Slug, to mouse chromosome 16 and human chromosome 8.
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| Rhim H, Savagner P, Thibaudeau G, Thiery JP, Pavan WJ.
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| Mamm Genome 8(11):872-3. 1997
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| 48 | SNAI2
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| The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition.
|
| Savagner P, et al.
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| J Cell Biol 137 : 1403-1419. 1997
|