Citations for
1IMP3, SNAI2, TAZ, WNT5B
IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer.
Samanta S, Guru S, Elaimy AL, Amante JJ, Ou J, Yu J, Zhu LJ, Mercurio AM.
Cell Rep 23(9):2559-2567. doi: 10.1016/j.celrep.2018.04.113. 2018
2PKNOX1, SNAI2
Prep1 (pKnox1) transcription factor contributes to pubertal mammary gland branching morphogenesis.
Sicouri L, Pisati F, Pece S, Blasi F, Longobardi E.
Int J Dev Biol 62(11-12):827-836. doi: 10.1387/ijdb.180278fb. 2018
3POU2F1, SNAI1, SNAI2, TWIST1, ZEB1
POU2F1 over-expression correlates with poor prognoses and promotes cell growth and epithelial-to-mesenchymal transition in hepatocellular carcinoma.
Zhong Y, Huang H, Chen M, Huang J, Wu Q, Yan GR, Chen.
Oncotarget 8(27):44082-44095. doi: 10.18632/oncotarget.17296. 2017
4SNAI2, TWIST1, ZHX1
Roles of zinc-fingers and homeoboxes 1 during the proliferation, migration, and invasion of glioblastoma cells.
Kwon RJ, Han ME, Kim YJ, Kim YH, Kim JY, Liu L, Heo W, Oh SO.
Tumour Biol. Mar;39(3):1010428317694575. doi: 10.1177/1010428317694575 2017
5SNAI1, SNAI2, VANGL1, ZEB1, ZEB2
KITENIN promotes glioma invasiveness and progression, associated with the induction of EMT and stemness markers.
Lee KH, Ahn EJ, Oh SJ, Kim O, Joo YE, Bae JA, Yoon S, Ryu HH, Jung S, Kim KK, Lee JH, Moon KS.
Oncotarget 6(5):3240-53. 2015
6AURKA, BRCA2, FBN1, SNAI2
Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis.
Wang Z, Liu Y, Lu L, Yang L, Yin S, Wang Y, Qi Z, Meng J, Zang R, Yang G.
Oncotarget 6(9):6670-83. 2015
7NANOG, SNAI1, SNAI2
A genome-wide RNAi screen identifies opposing functions of Snai1 and Snai2 on the Nanog dependency in reprogramming.
Gingold JA, Fidalgo M, Guallar D, Lau Z, Sun Z, Zhou H, Faiola F, Huang X, Lee DF, Waghray A, Schaniel C, Felsenfeld DP, Lemischka IR, Wang J.
Mol Cell 56(1):140-52. doi: 10.1016/j.molcel.2014.08.014. Epub 2014 Sep 15. 2014
8HMGA2, SNAI2
HMGA2 induces transcription factor Slug expression to promote epithelial-to-mesenchymal transition and contributes to colon cancer progression.
Li Y, Zhao Z, Xu C, Zhou Z, Zhu Z, You T.
Cancer Lett 355(1):130-40. doi: 10.1016/j.canlet.2014.09.007. Epub 2014 Sep 11. 2014
9SNAI1, SNAI2
DNA methylation is associated with transcription of Snail and Slug genes.
Chen Y, Wang K, Qian CN, Leach R.
Biochem Biophys Res Commun 430(3):1083-90. doi: 10.1016/j.bbrc.2012.12.034. Epub 2012 Dec 19. 2013
10SNAI2, SOX9
Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling.
Liu JA, Wu MH, Yan CH, Chau BK, So H, Ng A, Chan A, Cheah KS, Briscoe J, Cheung M.
Proc Natl Acad Sci U S A 110(8):2882-7. doi: 10.1073/pnas.1211747110. Epub 2013 Feb 4. 2013
11SNAI2, SOX9
Slug and Sox9 cooperatively determine the mammary stem cell state.
Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, Itzkovitz S, Noske A, Zürrer-Härdi U, Bell G, Tam WL, Mani SA, van Oudenaarden A, Weinberg RA.
Cell 148(5):1015-28. doi: 10.1016/j.cell.2012.02.008. 2012
12KLF4, SNAI2
Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor β-initiated prostate cancer epithelial-mesenchymal transition.
Liu YN, Abou-Kheir W, Yin JJ, Fang L, Hynes P, Casey O, Hu D, Wan Y, Seng V, Sheppard-Tillman H, Martin P, Kelly K.
Mol Cell Biol 32(5):941-53. doi: 10.1128/MCB.06306-11. Epub 2011 Dec 27. 2012
13PRDX1, SNAI1, SNAI2
Human peroxiredoxin 1 modulates TGF-β1-induced epithelial-mesenchymal transition through its peroxidase activity.
Ha B, Kim EK, Kim JH, Lee HN, Lee KO, Lee SY, Jang HH.
Biochem Biophys Res Commun 421(1):33-7. doi: 10.1016/j.bbrc.2012.03.103. Epub 2012 Mar 27. 2012
14CDH6, PHF12, SIN3A, SNAI2
A PHD12-Snail2 repressive complex epigenetically mediates neural crest epithelial-to-mesenchymal transition.
Strobl-Mazzulla PH, Bronner ME.
J Cell Biol 198(6):999-1010. doi: 10.1083/jcb.201203098. 2012
15SNAI2, TWIST1
Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis.
Casas E, Kim J, Bendesky A, Ohno-Machado L, Wolfe CJ, Yang J.
Cancer Res 71(1):245-54. 2011
16CCND1, SNAI2, UBE2D3
SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination.
Mittal MK, Singh K, Misra S, Chaudhuri G.
J Biol Chem 286(1):469-79. Epub 2010 Nov 2. 2011
17CXCL12, SNAI2
Slug contributes to the regulation of CXCL12 expression in human osteoblasts.
Piva R, Manferdini C, Lambertini E, Torreggiani E, Penolazzi L, Gambari R, Pastore A, Pelucchi S, Gabusi E, Piacentini A, Filardo G, Facchini A, Lisignoli G.
Exp Cell Res 317(8):1159-68. Epub 2010 Dec 21. 2011
18SNAI1, SNAI2, TCF3
Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis.
Lee K, Gjorevski N, Boghaert E, Radisky DC, Nelson CM.
EMBO J 30(13):2662-74. doi: 10.1038/emboj.2011.159. 2011
19SNAI2
Snail2 controls mesodermal BMP/Wnt induction of neural crest.
Shi J, Severson C, Yang J, Wedlich D, Klymkowsky MW.
Development 138(15):3135-45. Epub 2011 Jun 29. 2011
20SNAI2, ZEB1
Transcriptional activation of ZEB1 by Slug leads to cooperative regulation of the epithelial-mesenchymal transition-like phenotype in melanoma.
Wels C, Joshi S, Koefinger P, Bergler H, Schaider H.
J Invest Dermatol 131(9):1877-85. doi: 10.1038/jid.2011.142. Epub 2011 May 19. 2011
21MYB, SNAI2
Expression of Slug is regulated by c-Myb and is required for invasion and bone marrow homing of cancer cells of different origin.
Tanno B, Sesti F, Cesi V, Bossi G, Ferrari-Amorotti G, Bussolari R, Tirindelli D, Calabretta B, Raschellà G.
J Biol Chem 285(38):29434-45. Epub 2010 Jul 11. 2010
22SNAI2
SNAI2/Slug promotes growth and invasion in human gliomas.
Yang HW, Menon LG, Black PM, Carroll RS, Johnson MD.
BMC Cancer 10:301. 2010
23SNAI2
Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration.
Sun Y, Shao L, Bai H, Wang ZZ, Wu WS.
Blood 115(9):1709-17. Epub 2009 Dec 23. 2010
24SNAI2
Slug gene expression supports human osteoblast maturation.
Lambertini E, Lisignoli G, Torreggiani E, Manferdini C, Gabusi E, Franceschetti T, Penolazzi L, Gambari R, Facchini A, Piva R.
Cell Mol Life Sci 66(22):3641-53. Epub 2009 Sep 11. 2009
25SNAI2
Cutaneous wound reepithelialization is compromised in mice lacking functional Slug (Snai2).
Hudson LG, Newkirk KM, Chandler HL, Choi C, Fossey SL, Parent AE, Kusewitt DF.
J Dermatol Sci 56(1):19-26. Epub 2009 Jul 29. 2009
26MMP17, SNAI2
Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis.
Huang CH, Yang WH, Chang SY, Tai SK, Tzeng CH, Kao JY, Wu KJ, Yang MH.
Neoplasia 11(12):1371-82. 2009
27SNAI2
Switching in discoid domain receptor expressions in SLUG-induced epithelial-mesenchymal transition.
Maeyama M, Koga H, Selvendiran K, Yanagimoto C, Hanada S, Taniguchi E, Kawaguchi T, Harada M, Ueno T, Sata M.
Cancer 113(10):2823-31. 2008
28SNAI1, SNAI2
Slug is a direct Notch target required for initiation of cardiac cushion cellularization.
Niessen K, Fu Y, Chang L, Hoodless PA, McFadden D, Karsan A.
J Cell Biol 182(2):315-25. 2008
29SNAI2, SNAI3, SCRT1, SCRT2, CTBP1
Human SLUG does not directly bind to CtBP1.
Bailey CK, Misra S, Mittal MK, Chaudhuri G.
Biochem Biophys Res Commun 353(3):661-4. Epub 2006 Dec 22. 2007
30SNAI2
Adipose tissue mass is modulated by SLUG (SNAI2).
PŽrez-Mancera PA, Bermejo-Rodr’guez C, Gonz‡lez-Herrero I, Herranz M, Flores T, JimŽnez R, S‡nchez-Garc’a I.
Hum Mol Genet 16(23):2972-86. Epub 2007 Sep 28. 2007
31CDH6, SNAI2
Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest.
Taneyhill LA, Coles EG, Bronner-Fraser M.
Development 134(8):1481-90. Epub 2007 Mar 7. 2007
32SNAI1, SNAI2
Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesis.
Leroy P, Mostov KE.
Mol Biol Cell 18(5):1943-52. Epub 2007 Mar 7. 2007
33SLC6A2, SNAI2, SCRT1, SCRT2
A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder.
Kim CH, Hahn MK, Joung Y, Anderson SL, Steele AH, Mazei-Robinson MS, Gizer I, Teicher MH, Cohen BM, Robertson D, Waldman ID, Blakely RD, Kim KS.
Proc Natl Acad Sci U S A 103(50):19164-9. Epub 2006 Dec 4. 2006
34PRSS8, SNAI2
Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG.
Chen M, Chen LM, Chai KX.
Prostate 66(9):911-20. 2006
35AHR, SNAI2
Zinc finger transcription factor Slug is a novel target gene of aryl hydrocarbon receptor.
Ikuta T, Kawajiri K.
Exp Cell Res 312(18):3585-94. Epub 2006 Aug 9. 2006
36SNAI2
Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma.
Wu WS, Heinrichs S, Xu D, Garrison SP, Zambetti GP, Adams JM, Look AT.
Cell 123(4):641-53. 2005
37SNAI2
Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells.
Tripathi MK, Misra S, Khedkar SV, Hamilton N, Irvin-Wilson C, Sharan C, Sealy L, Chaudhuri G.
J Biol Chem 280(17):17163-71. Epub 2005 Feb 24. 2005
38SNAI2
SLUG in cancer development.
Perez-Mancera PA, Gonzalez-Herrero I, Perez-Caro M, Gutierrez-Cianca N, Flores T, Gutierrez-Adan A, Pintado B, Sanchez-Martin M, Sanchez-Garcia I.
Oncogene 24(19):3073-82. 2005
39SNAI2, VDR
The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer.
Palmer HG, Larriba MJ, Garcia JM, Ordonez-Moran P, Pena C, Peiro S, Puig I, Rodriguez R, De La Fuente R, Bernad A, Pollan M, Bonilla F, Gamallo C, De Herreros AG, Munoz A.
Nat Med 10(9):917-9. Epub 2004 Aug 22. 2004
40PBT2, SNAI2
Deletion of the SLUG (SNAI2) gene results in human piebaldism.
Sanchez-Martin M, Perez-Losada J, Rodriguez-Garcia A, Gonzalez-Sanchez B, Korf BR, Kuster W, Moss C, Spritz RA, Sanchez-Garcia I.
Am J Med Genet 122A(2):125-32. 2003
41SNAI2, WS2D
SLUG (SNAI2) deletions in patients with Waardenburg disease.
Sanchez-Martin M, Rodriguez-Garcia A, Perez-Losada J, Sagrera A, Read AP, Sanchez-Garcia I.
Hum Mol Genet 11(25):3231-6. 2002
42SNAI2
The SLUG zinc-finger protein represses E-cadherin in breast cancer.
Hajra KM, Chen DY, Fearon ER.
Cancer Res 62(6):1613-8. 2002
43SNAI2, SNAI1
Identification and analysis of two snail genes in the pufferfish (Fugu rubripes) and mapping of human SNA to 20q.
Smith S, Metcalfe JA, Elgar G.
Gene 247(1-2):119-28. 2000
44SNAI2
SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein.
Inukai T, Inoue A, Kurosawa H, Goi K, Shinjyo T, Ozawa K, Mao M, Inaba T, Look AT.
Mol Cell 4(3):343-52 1999
45SNAI2
Human SLUG gene organization, expression, and chromosome map location on 8q.
Cohen ME, et al.
Genomics 51 : 468-471. 1998
46SNAI2
Localization of a neural crest transcription factor, Slug, to mouse chromosome 16 and human chromosome 8.
Rhim H, Savagner P, Thibaudeau G, Thiery JP, Pavan WJ.
Mamm Genome 8(11):872-3. 1997
47SNAI2
The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition.
Savagner P, et al.
J Cell Biol 137 : 1403-1419. 1997