Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

IL10

contributors: mct - updated : 17-11-2017

HGNC name	interleukin 10
HGNC id	5962

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation     loss of function loss of function mutations in interleukin-10 (IL10) and interleukin-10 receptors (IL10R) cause severe infantile (very early onset) inflammatory bowel disease (IBD) tumoral     --over   in diffuse large B-cell lymphoma, patients with high serum IL10 had shorter event-free survival (EFS) than patients with low levels constitutional     --over   DNA hypomethylation leads to IL10 and IL13 overexpression in systemic lupus erythematosus patients constitutional     --low   is associated with risk of Behçet disease (BD)

Susceptibility

to hepatocellular carcinoma (HCC) to acute myocardial infarction to Wegener's granulomatosis to sudden infant death with infectious cause to SLE systemic lupus erythematosus to severe malarial anemia to leprosy

Variant & Polymorphism SNP , repeat , other	CA repeat in IL10 associated with WG
	IL10 HT2 accelerates progression of chronic hepatitis B virus infection especially to HCC development
	1082GG genotype protecting against myocardial infarction
	CA repeat polymorphism IL-10.G, associated with Wegener's granulomatosis
	alleles G21/G22 and G21/G23, associated with infectious cause of sudden infant death
	SNP 819T is associated with leprosy susceptibility
	haplotypes of IL10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL10 production
	rs3024505 significantly associated to SLE

Candidate gene
Marker	may be a biomarker to identify patients more likely to respond to JAK2-targeted therapy, in diffuse large B-cell lymphoma
Therapy target

ANIMAL & CELL MODELS

IL10 deficiency affects the immune functions of dendritic cells, which may contribute to the increased severity of autoimmune diseases seen in IL-10(-/-) mice (