| 1 | GPR39, IL10
|
| G protein-coupled receptor 39 plays an anti-inflammatory role by enhancing IL-10 production from macrophages under inflammatory conditions.
|
| Muneoka S, Goto M, Kadoshima-Yamaoka K, Kamei R, Terakawa M, Tomimori Y.
|
| Eur J Pharmacol 834:240-245. doi: 10.1016/j.ejphar.2018.07.045. Epub 2018 Jul 24.
2018
|
| 2 | CCR1, IL10
|
| GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Behçet's disease.
|
| Nakano H, Kirino Y, Takeno M, Higashitani K, Nagai H, Yoshimi R, Yamaguchi Y, Kato I, Aoki I, Nakajima H.
|
| Arthritis Res Ther 20(1):124. doi: 10.1186/s13075-018-1613-0.
2018
|
| 3 | CRP, IL10
|
| Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands.
|
| Pilling D, Galvis-Carvajal E, Karhadkar TR, Cox N, Gomer RH.
|
| BMC Immunol 18(1):30. doi: 10.1186/s12865-017-0214-z.
2017
|
| 4 | ETV5, IL10
|
| Etv5 Regulates IL-10 Production in Th Cells.
|
| Koh B, Hufford MM, Sun X, Kaplan MH.
|
| J Immunol 198(5):2165-2171. doi: 10.4049/jimmunol.1600801. Epub 2017 Jan 18.
2017
|
| 5 | IL10, IL23R, RBPJ
|
| RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression.
|
| Meyer Zu Horste G, Wu C, Wang C, Cong L, Pawlak M, Lee Y, Elyaman W, Xiao S, Regev A, Kuchroo VK.
|
| Cell Rep 16(2):392-404. doi: 10.1016/j.celrep.2016.05.088. Epub 2016 Jun 23.
2016
|
| 6 | IFNB1, IL10, SYK, TLR4
|
| Syk negatively regulates TLR4-mediated IFNβ and IL-10 production and promotes inflammatory responses in dendritic cells.
|
| Yin H, Zhou H, Kang Y, Zhang X, Duan X, Alnabhan R, Liang S, Scott DA, Lamont RJ, Shang J, Wang H.
|
| Biochim Biophys Acta 1860(3):588-98. doi: 10.1016/j.bbagen.2015.12.012. Epub 2015 Dec 17.
2016
|
| 7 | HAVCR2, IL10, IL27, NFIL3
|
| An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction.
|
| Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK.
|
| Nat Commun 6:6072. doi: 10.1038/ncomms7072. Erratum in: Nat Commun. 2015;6:7657.
2015
|
| 8 | IL10, IL12A, MAP2K1, TLR4
|
| MEK1 dependent and independent ERK activation regulates IL-10 and IL-12 production in bone marrow derived macrophages.
|
| Bouhamdan M, Bauerfeld C, Talreja J, Beuret L, Charron J, Samavati L.
|
| Cell Signal 27(10):2068-76. doi: 10.1016/j.cellsig.2015.07.015. Epub 2015 Jul 21.
2015
|
| 9 | IL10, MEF2D
|
| Transcription factor myocyte enhancer factor 2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death.
|
| Yang S, Gao L, Lu F, Wang B, Gao F, Zhu G, Cai Z, Lai J, Yang Q.
|
| J Neuroinflammation 12:33. doi: 10.1186/s12974-015-0258-z.
2015
|
| 10 | IL10, PDCD1
|
| PD-1 modulates steady-state and infection-induced IL-10 production in vivo.
|
| McBerry C, Dias A, Shryock N, Lampe K, Gutierrez FR, Boon L, De'Broski RH, Aliberti J.
|
| Eur J Immunol 44(2):469-79. doi: 10.1002/eji.201343658.
2014
|
| 11 | ID2, IL10, TCF3
|
| Id2 represses E2A-mediated activation of IL-10 expression in T cells.
|
| Masson F, Ghisi M, Groom JR, Kallies A, Seillet C, Johnstone RW, Nutt SL, Belz GT.
|
| Blood 123(22):3420-8. doi: 10.1182/blood-2014-03-561456. Epub 2014 Apr 10.
2014
|
| 12 | IL10, MYD88, TLR4
|
| Interleukin-10 activates Toll-like receptor 4 and requires MyD88 for cardiomyocyte survival.
|
| Bagchi AK, Sharma A, Dhingra S, Lehenbauer Ludke AR, Al-Shudiefat AA, Singal PK.
|
| Cytokine 61(1):304-14. doi: 10.1016/j.cyto.2012.10.013. Epub 2012 Nov 8.
2013
|
| 13 | IL10, SLC6A4
|
| IL-10 modulates serotonin transporter activity and molecular expression in intestinal epithelial cells.
|
| Latorre E, Mendoza C, Matheus N, Castro M, Grasa L, Mesonero JE, Alcalde AI.
|
| Cytokine 61(3):778-84. doi: 10.1016/j.cyto.2013.01.012. Epub 2013 Feb 12.
2013
|
| 14 | IL10, MARCHF1
|
| MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression.
|
| Galbas T, Steimle V, Lapointe R, Ishido S, Thibodeau J.
|
| Cytokine 59(1):27-30. Epub 2012 Apr 12. 2012
|
| 15 | IL10
|
| The T cell response to IL-10 alters cellular dynamics and paradoxically promotes central nervous system autoimmunity.
|
| Liu X, Alli R, Steeves M, Nguyen P, Vogel P, Geiger TL.
|
| J Immunol 189(2):669-78. Epub 2012 Jun 18.
2012
|
| 16 | IL10
|
| IL-10 deficiency blocks the ability of LPS to regulate expression of tolerance-related molecules on dendritic cells.
|
| Zhou F, Ciric B, Li H, Yan Y, Li K, Cullimore M, Lauretti E, Gonnella P, Zhang GX, Rostami A.
|
| Eur J Immunol 42(6):1449-58. doi: 10.1002/eji.201141733. Epub 2012 May 23.
2012
|
| 17 | CAMK2B, IL10
|
| Calcium/calmodulin-dependent protein kinase II regulates IL-10 production by human T lymphocytes: a distinct target in the calcium dependent pathway.
|
| Boubali S, Liopeta K, Virgilio L, Thyphronitis G, Mavrothalassitis G, Dimitracopoulos G, Paliogianni F.
|
| Mol Immunol 52(2):51-60. Epub 2012 May 10.
2012
|
| 18 | IL10, IL10RA
|
| Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.
|
| Kotlarz D, Beier R, Murugan D, Diestelhorst J, Jensen O, Boztug K, Pfeifer D, Kreipe H, Pfister ED, Baumann U, Puchalka J, Bohne J, Egritas O, Dalgic B, Kolho KL, Sauerbrey A, Buderus S, Güngör T, Enninger A, Koda YK, Guariso G, Weiss B, Corbacioglu S, Socha P, Uslu N, Metin A, Wahbeh GT, Husain K, Ramadan D, Al-Herz W, Grimbacher B, Sauer M, Sykora KW, Koletzko S, Klein C.
|
| Gastroenterology 143(2):347-55. Epub 2012 Apr 28. 2012
|
| 19 | IL10, PBRM1
|
| IL-10 transcription is negatively regulated by BAF180, a component of the SWI/SNF chromatin remodeling enzyme.
|
| Wurster AL, Precht P, Becker KG, Wood WH 3rd, Zhang Y, Wang Z, Pazin MJ.
|
| BMC Immunol 13:9.
2012
|
| 20 | IL10
|
| Elevated serum IL-10 levels in diffuse large B-cell lymphoma: a mechanism of aberrant JAK2 activation.
|
| Gupta M, Han JJ, Stenson M, Maurer M, Wellik L, Hu G, Ziesmer S, Dogan A, Witzig TE.
|
| Blood 119(12):2844-53. Epub 2012 Feb 8.
2012
|
| 21 | IL10, IL10RA, IL10RB
|
| Association between IL10, IL10RA, and IL10RB SNPs and ischemic stroke with hypertension in Korean population.
|
| Park HK, Kim DH, Yun DH, Ban JY.
|
| Mol Biol Rep ol Biol Rep. 2012 Oct 21. [Epub ahead of print]
2012
|
| 22 | HDAC3, IL10, IL12B
|
| IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.
|
| Kobayashi T, Matsuoka K, Sheikh SZ, Russo SM, Mishima Y, Collins C, deZoeten EF, Karp CL, Ting JP, Sartor RB, Plevy SE.
|
| J Immunol 189(4):1792-9. doi: 10.4049/jimmunol.1200042. Epub 2012 Jul 11.
2012
|
| 23 | ABCA1, IL10, PRKACA
|
| ABCA1 protein enhances Toll-like receptor 4 (TLR4)-stimulated interleukin-10 (IL-10) secretion through protein kinase A (PKA) activation.
|
| Ma L, Dong F, Zaid M, Kumar A, Zha X.
|
| J Biol Chem 287(48):40502-12. doi: 10.1074/jbc.M112.413245. Epub 2012 Oct 10.
2012
|
| 24 | IL10, IL22
|
| Regulation of interleukin-10 and interleukin-22 expression in T helper cells.
|
| Rutz S, Ouyang W.
|
| Curr Opin Immunol 23(5):605-12. Epub 2011 Aug 20. Review.
2011
|
| 25 | IL10
|
| IL-10 Prevents apoptosis of brain endothelium during bacteremia.
|
| Londoño D, Carvajal J, Strle K, Kim KS, Cadavid D.
|
| J Immunol 186(12):7176-86. Epub 2011 May 20.
2011
|
| 26 | IL10
|
| Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation.
|
| Chaudhry A, Samstein RM, Treuting P, Liang Y, Pils MC, Heinrich JM, Jack RS, Wunderlich FT, Brüning JC, Müller W, Rudensky AY.
|
| Immunity 34(4):566-78.
2011
|
| 27 | IL10, IRF4
|
| IRF4 regulates IL-10 gene expression in CD4(+) T cells through differential nuclear translocation.
|
| Lee CG, Hwang W, Maeng KE, Kwon HK, So JS, Sahoo A, Lee SH, Park ZY, Im SH.
|
| Cell Immunol 268(2):97-104. Epub 2011 Mar 4.
2011
|
| 28 | IFNB1, IL10
|
| The role of glycogen synthase kinase 3 in regulating IFN-β-mediated IL-10 production.
|
| Wang H, Brown J, Garcia CA, Tang Y, Benakanakere MR, Greenway T, Alard P, Kinane DF, Martin M.
|
| J Immunol 186(2):675-84. Epub 2010 Dec 15.
2011
|
| 29 | IL10, IL12B, NFIL3
|
| A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3.
|
| Smith AM, Qualls JE, O'Brien K, Balouzian L, Johnson PF, Schultz-Cherry S, Smale ST, Murray PJ.
|
| J Biol Chem 286(26):23582-90. doi: 10.1074/jbc.M111.249235. Epub 2011 May 12.
2011
|
| 30 | IL10
|
| Neutrophils are significant producers of IL-10 during sepsis.
|
| Kasten KR, Muenzer JT, Caldwell CC.
|
| Biochem Biophys Res Commun 393(1):28-31. Epub 2010 Jan 25.
2010
|
| 31 | IL10, TNF
|
| IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages.
|
| Smallie T, Ricchetti G, Horwood NJ, Feldmann M, Clark AR, Williams LM.
|
| J Exp Med 207(10):2081-8. Epub 2010 Aug 30.
2010
|
| 32 | IL10, TNF
|
| IL-10 and TNF-alpha promoter polymorphisms in susceptibility to systemic lupus erythematosus in Taiwan.
|
| Lin YJ, Wan L, Huang CM, Sheu JJ, Chen SY, Lin TH, Chen DY, Hsueh KC, Lai CC, Tsai FJ.
|
| Clin Exp Rheumatol 28(3):318-24. Epub 2010 Jun 23.
2010
|
| 33 | IL10, IL22, IL26
|
| Interleukin-26: an IL-10-related cytokine produced by Th17 cells.
|
| Donnelly RP, Sheikh F, Dickensheets H, Savan R, Young HA, Walter MR.
|
| Cytokine Growth Factor Rev 21(5):393-401. Epub 2010 Oct 14. Review. 2010
|
| 34 | IL10, IL13
|
| Hypomethylation of IL10 and IL13 promoters in CD4+ T cells of patients with systemic lupus erythematosus.
|
| Zhao M, Tang J, Gao F, Wu X, Liang Y, Yin H, Lu Q.
|
| J Biomed Biotechnol 2010:931018. Epub 2010 Jun 2.
2010
|
| 35 | IL10
|
| Genetic, epidemiological and biological analysis of interleukin-10 promoter single-nucleotide polymorphisms suggests a definitive role for -819C/T in leprosy susceptibility.
|
| Pereira AC, Brito-de-Souza VN, Cardoso CC, Dias-Baptista IM, Parelli FP, Venturini J, Villani-Moreno FR, Pacheco AG, Moraes MO.
|
| Genes Immun 10(2):174-80. Epub 2008 Dec 25.
2009
|
| 36 | IL10, PTPN6
|
| IL-10 suppresses CD2-mediated T cell activation via SHP-1.
|
| Taylor A, Verhagen J, Akkoç T, Wenig R, Flory E, Blaser K, Akdis M, Akdis CA.
|
| Mol Immunol 46(4):622-9. Epub 2008 Oct 25.
2009
|
| 37 | IL10, JUN
|
| c-jun controls the ability of IL-12 to induce IL-10 production from human memory CD4+ T cells.
|
| Garcia CA, Wang H, Benakanakere MR, Barrett E, Kinane DF, Martin M.
|
| J Immunol 183(7):4475-82. Epub 2009 Sep 4.PMID: 19734233 2009
|
| 38 | IL10, JAZF1, PRDM1, TNIP1, UHRF1BP1
|
| A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
|
| Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X, Ortmann W, Kosoy R, Ferreira RC, Nordmark G, Gunnarsson I, Svenungsson E, Padyukov L, Sturfelt G, Jönsen A, Bengtsson AA, Rantapää-Dahlqvist S, Baechler EC, Brown EE, Alarcón GS, Edberg JC, Ramsey-Goldman R, McGwin G Jr, Reveille JD, Vilá LM, Kimberly RP, Manzi S, Petri MA, Lee A, Gregersen PK, Seldin MF, Rönnblom L, Criswell LA, Syvänen AC, Behrens TW, Graham RR.
|
| Nat Genet 41(11):1228-33. Epub 2009 Oct 18.PMID: 19838195 2009
|
| 39 | IL10, IL10RB
|
| Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor.
|
| Sivula J, Turpeinen H, Volin L, Partanen J.
|
| BMC Immunol 10:24. doi: 10.1186/1471-2172-10-24.
2009
|
| 40 | IL10, IL17, IL27
|
| IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells.
|
| Murugaiyan G, Mittal A, Lopez-Diego R, Maier LM, Anderson DE, Weiner HL.
|
| J Immunol 183(4):2435-43. doi: 10.4049/jimmunol.0900568. Epub 2009 Jul 22.
2009
|
| 41 | IL10
|
| Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production.
|
| Ouma C, Davenport GC, Were T, Otieno MF, Hittner JB, Vulule JM, Martinson J, Ong'echa JM, Ferrell RE, Perkins DJ.
|
| Hum Genet 124(5):515-24. Epub 2008 Oct 30.
2008
|
| 42 | IL10, TNF
|
| IL-10 overexpression differentially affects cartilage matrix gene expression in response to TNF-alpha in human articular chondrocytes in vitro.
|
| Müller RD, John T, Kohl B, Oberholzer A, Gust T, Hostmann A, Hellmuth M, Laface D, Hutchins B, Laube G, Veh RW, Tschoeke SK, Ertel W, Schulze-Tanzil G.
|
| Cytokine 44(3):377-85. Epub 2008 Nov 20.
2008
|
| 43 | ADAM17, IL10
|
| Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism.
|
| Brennan FM, Green P, Amjadi P, Robertshaw HJ, Alvarez-Iglesias M, Takata M.
|
| Eur J Immunol 38(4):1106-17.PMID: 18383040 2008
|
| 44 | IL10, IL10RA
|
| Circulating neutrophils of septic patients constitutively express IL-10R1 and are promptly responsive to IL-10.
|
| Tamassia N, Calzetti F, Menestrina N, Rossato M, Bazzoni F, Gottin L, Cassatella MA.
|
| Int Immunol 20(4):535-41. Epub 2008 Feb 27.
2008
|
| 45 | IL1B, IL10, IL6, TGFB1
|
| [Genetic markers of predisposition to an aggressive course of chronic C hepatitis]
|
| Abdullaev SM, Tselishcheva IuI, Samokhodskaia LM, Kvasovka VV, Ignatova TM, Krasnova TN, Bochkov VN, Mukhin NA.
|
| Vestn Ross Akad Med Nauk (1):8-13. Russian. 2007
|
| 46 | IL10
|
| Interleukin-10 is not a critical regulator of infarct healing and left ventricular remodeling.
|
| Zymek P, Nah DY, Bujak M, Ren G, Koerting A, Leucker T, Huebener P, Taffet G, Entman M, Frangogiannis NG.
|
| Cardiovasc Res 74(2):313-22. Epub 2006 Nov 23.
2007
|
| 47 | IL10, STAT3, BTK
|
| Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3.
|
| Kawakami Y, Inagaki N, Salek-Ardakani S, Kitaura J, Tanaka H, Nagao K, Kawakami Y, Xiao W, Nagai H, Croft M, Kawakami T.
|
| Proc Natl Acad Sci U S A 103(1):153-8. Epub 2005 Dec 21. 2006
|
| 48 | IL10
|
| Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease.
|
| Lio D, Candore G, Crivello A, Scola L, Colonna-Romano G, Cavallone L, Hoffmann E, Caruso M, Licastro F, Caldarera CM, Branzi A, Franceschi C, Caruso C.
|
| J Med Genet 41(10):790-4. No abstract available. 2004
|
| 49 | IL10
|
| Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma.
|
| Shin HD, Park BL, Kim LH, Jung JH, Kim JY, Yoon JH, Kim YJ, Lee HS.
|
| Hum Mol Genet 12(8):901-6. 2003
|
| 50 | IL10
|
| IL-10 gene polymorphisms are associated with infectious cause of sudden infant death.
|
| Opdal SH, Opstad A, Vege A, Rognum TO.
|
| Hum Immunol 64(12):1183-9. 2003
|
| 51 | IL10
|
| Novel genetic association of Wegener's granulomatosis with the interleukin 10 gene.
|
| Zhou Y, Giscombe R, Huang D, Lefvert AK.
|
| J Rheumatol 29(2):317-20. 2002
|
| 52 | CCR5, CD4, IL10, IL4
|
| Regulation of CC chemokine receptor 5 and CD4 expression and human immunodeficiency virus type 1 replication in human macrophages and microglia by T helper type 2 cytokines.
|
| Wang J, Crawford K, Yuan M, Wang H, Gorry PR, Gabuzda D.
|
| J Infect Dis 185(7):885-97. 2002
|
| 53 | CD320, IL10, IL4
|
| The distinct roles of T cell-derived cytokines and a novel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation.
|
| Zhang X, Li L, Jung J, Xiang S, Hollmann C, Choi YS.
|
| J Immunol 167(1):49-56. 2001
|
| 54 | IL10
|
| Mapping of the human IL10 gene and further characterization of the 5' flanking sequence.
|
| Eskdale J, Kube D, Tesch H, Gallagher G.
|
| Immunogenetics 46(2):120-8. 1997
|
| 55 | IL10
|
| A second polymorphic dinucleotide repeat in the 5' flanking region of the human IL10 gene.
|
| Eskdale J, et al.
|
| Immunogenetics 45 : 82-83. 1996
|
| 56 | IL10
|
| Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes.
|
| Kim JM, et al.
|
| J Immunol 148 : 3618-3623. 1992
|
| 57 | IL10, IFNG, CSF2
|
| Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies.
|
| Pisa P, et al.
|
| Proc Natl Acad Sci U S A 89 : 7708-7712. 1992
|
| 58 | IL10
|
| Human B-cell interleukin-10 : B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10.
|
| Benjamin D, et al.
|
| Blood 80 : 1289-1298. 1992
|
| 59 | IL10
|
| Isolation and expression of human cytokine synthesis inhibitory factor (CSIF/IL10) cDNA clones : homology to Epstein-Barr virus open reading frame BCRF1.
|
| Vieira P, et al.
|
| Proc Natl Acad Sci U S A 88 : 1172-1176. 1991
|