| basic FUNCTION
| cytokine synthesis inhibitory factor |
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costimulator of proliferation and differentiation of B, T, mast cell |
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exerts potent anti-inflammatory actions and modulates matrix metalloproteinase expression  |
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chemotactor for CD8+ T cells |
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involved in regulating the intensity and duration of the immune response |
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playing an important role in the development of infectious disease |
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directing germinal center-B cells to differentiate into plasma cells |
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IL10 signaling plays a non-critical role in suppression of inflammatory mediators, resolution of the inflammatory response, and fibrous tissue deposition following myocardial infarction |
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important immunoregulatory cytokine that functions to downregulate immune responses |
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regulates ADAM17, involving a TIMP3 dependent and independent mechanism) |
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IL10 and IL13 play important roles in Th2 cell differentiation and production of autoantibodies in patients with (SLE) |
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inhibits transcription elongation of the human TNF gene in primary macrophages |
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multi-functional cytokine that plays a crucial role in maintaining the balance between immunity and tolerance |
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anti-inflammatory interleukin-10 (IL10), endowed Treg cells with the ability to suppress pathogenic Th17 cell responses |
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prevents apoptosis of brain endothelium during bacteremia |
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IL10 and IL22 are crucial regulators of inflammation during immune responses, and IL10 functions to prevent excessive inflammation by acting on immune cells |
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critical anti-inflammatory cytokine, the deficiency of which leads to spontaneous autoimmunity |
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T cell specific actions of IL10 can support autoimmune inflammation, and this appears to result from an overall increase in the long term fitness of pathologic T cells |
