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FLASH GENE
Symbol LIM2 contributors: mct - updated : 25-10-2018
HGNC name lens intrinsic membrane protein 2, 19kDa
HGNC id 6610
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a four transmembrane segments (TM4)
    • mono polymer homomer , heteromer
    HOMOLOGY
    interspecies homolog to murine Lim2 (91.33 pc)
    homolog to rattus Lim2 (91.91 pc)
    Homologene
    FAMILY PMP22/EMP/MP20 family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    basic FUNCTION
  • water channel properties
  • contributing to cell junctional organization in both lens development and cataractogenesis
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • associated with itself or another lens membrane component via disulfide bonds
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CATPS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS