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FLASH GENE

Symbol

LIM2

contributors: mct - updated : 25-10-2018

HGNC name	lens intrinsic membrane protein 2, 19kDa
HGNC id	6610

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	8.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed - - splicing 970 24.5 215 - Wistow - - splicing 860 19.7 173 - Wistow

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye       specific

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective       lowly

cells

System Cell Pubmed Species Stage Rna symbol Visual lens fibers

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a four transmembrane segments (TM4)

mono polymer

homomer , heteromer

HOMOLOGY

interspecies	homolog to murine Lim2 (91.33 pc)
	homolog to rattus Lim2 (91.91 pc)

Homologene

FAMILY

PMP22/EMP/MP20 family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION

plasma membrane,junction

basic FUNCTION	water channel properties
	contributing to cell junctional organization in both lens development and cataractogenesis

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

associated with itself or another lens membrane component via disulfide bonds

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CATPS

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS