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FLASH GENE

Symbol

GABRE

contributors: - updated : 11-02-2004

HGNC name	gamma-aminobutyric acid (GABA) A receptor, epsilon
HGNC id	4085

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a ligand binding site in the N terminal region, four transmembrane segments,one of which forming the wall of the channel and a large intracellular loop

mono polymer

pentamer

HOMOLOGY

interspecies

homolog to murine Gabre

Homologene

FAMILY

ligand gated ionic channel family

CATEGORY

receptor membrane ligand ion channel

SUBCELLULAR LOCALIZATION

basic FUNCTION

multisubunit chloride channel mediating the fastest inhibitory synaptic transmission in the central nervous system.

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of a pentameric receptor mediating inhibitory neurotransmission

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS