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FLASH GENE

Symbol

GABRE

contributors: - updated : 11-02-2004

HGNC name	gamma-aminobutyric acid (GABA) A receptor, epsilon
HGNC id	4085

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain         Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a ligand binding site in the N terminal region, four transmembrane segments,one of which forming the wall of the channel and a large intracellular loop

mono polymer

pentamer

HOMOLOGY

interspecies

homolog to murine Gabre

Homologene

FAMILY

ligand gated ionic channel family

CATEGORY

receptor membrane ligand ion channel

SUBCELLULAR LOCALIZATION

basic FUNCTION

multisubunit chloride channel mediating the fastest inhibitory synaptic transmission in the central nervous system.

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of a pentameric receptor mediating inhibitory neurotransmission

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS