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FLASH GENE

Symbol

DSG3

contributors: mct - updated : 22-08-2014

HGNC name	desmoglein 3 (pemphigus vulgaris antigen)
HGNC id	3050

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   in Pemphigus vulgaris, autoantibodies generated target the desmosomal cadherin desmoglein-3 (DSG3) tumoral     --over   in head neck cancer

Susceptibility

to pemphigus vulgaris (PV) and herpetiform pemphigus, (autoantigen)

Variant & Polymorphism other	genetic variation may be an additive risk factor predisposing to PV

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer head and neck   target in the development of adjuvant therapy for head neck cancer

ANIMAL & CELL MODELS