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FLASH GENE
Symbol DSG3 contributors: mct - updated : 22-08-2014
HGNC name desmoglein 3 (pemphigus vulgaris antigen)
HGNC id 3050
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --other  
in Pemphigus vulgaris, autoantibodies generated target the desmosomal cadherin desmoglein-3 (DSG3)
tumoral     --over  
in head neck cancer
Susceptibility to pemphigus vulgaris (PV) and herpetiform pemphigus, (autoantigen)
Variant & Polymorphism other genetic variation may be an additive risk factor predisposing to PV
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerhead and neck 
target in the development of adjuvant therapy for head neck cancer
ANIMAL & CELL MODELS