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FLASH GENE

Symbol

TMPRSS2

contributors: mct/pgu - updated : 02-04-2020

HGNC name	transmembrane protease, serine 2
HGNC id	11876

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostate carcinoma, with down-regulation of KLK11 gene in advanced and more aggressive tumors may open the feasibility of being used as biomarkers distinguishing the tumor aggressiveness tumoral fusion       with ERG, ETV1 and ETV4 in prostate cancer tumoral somatic mutation translocation     Loss of PTEN and concomitant activation of AKTcould act in partnership with the TMPRSS2-ERG fusion protein to promote progression to prostate cancer tumoral fusion       TMPRSS2-ERG gene fusions were observed in 44p 100 of prostate cancer, and over 90p100 of these fusions occurred in ERG exons 3 or 4

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	development of the TMPRSS2-ERG fusion gene is a noninvasive tumor marker for therapy assessment, risk stratification, and relapse detection to improve personalized therapy strategies for patients with prostate cancer
	urinary TMPRSS2:ERG might become a valuable test not only for diagnosing PCa but also for distinguishing the aggressive tumors from the indolent ones
Therapy target
	System Type Disorder Pubmed immunology infectious   TMPRSS2-related therapeutic agents may be a promising countermeasure against the current and new outbreaks of CoVs

ANIMAL & CELL MODELS

Tmprss2 plays a crucial role in viral spread within the airway of murine models infected by SARS-CoV and MERS-CoV and in the resulting immunopathology