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FLASH GENE

Symbol

SMS

contributors: mct/npt - updated : 25-02-2009

HGNC name	spermine synthase
HGNC id	11123

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

Male gyro (Gy) mice, which have an X chromosomal deletion inactivating the SmS and Phex genes, were found to be profoundly hearing impaired, and showed a striking toxic response to treatment with the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) (Wang 2009)