|
| overexpression of Gsk3b in conditional transgenic mice results in hyperphosphorylation of tau and neurodegeneration | |
Gsk3b-deficient mice embryos show severe liver degeneration, a phenotype consistent with excessive tummor nercrosis factor |
|
Xenopus dominant negative mutants induced dorsal differentiation |
|
alterations of GSK3 profoundly affect neuronal morphology in culture |
|
knockdown of both GSK3B markedly reduced axon growth in dissociated cultures |
|
Homozygous null mice display cleft palate, incomplete fusion of the ribs at the midline and bifid sternum as well as delayed sternal ossification |
|
Gsk3b knockin mice (Tph2) show a markedly reduced brain serotonin (5-HT) neurotransmission production and behavioral abnormalities in tests assessing 5-HT-mediated emotional states |
|
Gsk3b-/- mice exhibit hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation |
|
concomitant loss of Gsk3a and Gsk3b in the oocyte significantly increased neonatal death rate due to congestive heart failur |