| 1 | CBX2, GSK3B, USP27X
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| Phosphorylation of USP27X by GSK3β maintains the stability and oncogenic functions of CBX2.
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| Xing Y, Ba-Tu J, Dong C, Cao X, Li B, Jia X, Juan Y, Lv X, Zhang H, Qin N, Han W, Wang D, Qi X, Wang Y, Hao X, Zhang S, Du X, Wang H, Wang M.
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| Cell Death Dis. Nov 29;14(11):782. doi: 10.1038/s41419-023-06304-y. 2023
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| 2 | BRD7, GSK3B, NFE2L2
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| Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner.
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| Yu X, Jiang N, Li J, Li X, He S.
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| Tissue Cell. Jun;76:101813. doi: 10.1016/j.tice.2022.101813. Epub 2022 2022
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| 3 | AMBRA1, GSK3B, HUWE1, MCL1
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| HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy.
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| Strappazzon F, Di Rita A, Peschiaroli A, Leoncini PP, Locatelli F, Melino G, Cecconi F.
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| Cell Death Differ :.
2019
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| 4 | GSK3B, PIWIL2
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| PIWIL2 stabilizes β-catenin to promote cell cycle and proliferation in tumor cells.
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| Qiu B, Zeng J, Zhao X, Huang L, Ma T, Zhu Y, Liu M, Tao D, Liu Y, Lu Y, Ma Y.
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| Biochem Biophys Res Commun. Aug 27;516(3):819-824. doi: 10.1016/j.bbrc.2019.06.136. Epub 2019 Jun 28. 2019
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| 5 | GSK3B, KDM1A, STIP1
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| Stress-induced phosphoprotein 1 acts as a scaffold protein for glycogen synthase kinase-3 beta-mediated phosphorylation of lysine-specific demethylase 1.
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| Tsai CL, Chao AS, Jung SM, Lin CY, Chao A, Wang TH.
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| Oncogenesis 7(3):31. doi: 10.1038/s41389-018-0040-z.
2018
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| 6 | BCL2L14, CASQ2, DLK1, GSK3B, GSK3B, HOXB8, KIF18A, TNFSF14
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| Gene expression profiling of osteoblasts subjected to dexamethasone-induced apoptosis with/without GSK3β-shRNA.
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| Nie Z, Chen S, Deng S, Long L, Peng P, Gao M, Cheng S, Cao J, Peng H.
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| Biochem Biophys Res Commun 506(1):41-47. doi: 10.1016/j.bbrc.2018.10.043. Epub 2018 Oct 15.
2018
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| 7 | GIMAP5, GSK3B
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| Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology.
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| Patterson AR, Endale M, Lampe K, Aksoylar HI, Flagg A, Woodgett JR, Hildeman D, Jordan MB, Singh H, Kucuk Z, Bleesing J, Hoebe K.
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| Nat Commun. Jan 30;9(1):430. doi: 10.1038/s41467-018-02897-7. 2018
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| 8 | GSK3B, KIF2B, KNSTRN
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| Phosphorylation of SKAP by GSK3β ensures chromosome segregation by a temporal inhibition of Kif2b activity.
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| Qin B, Cao D, Wu H, Mo F, Shao H, Chu J, Powell M, Aikhionbare F, Wang D, Fu C, He P, Pan W, Wang W, Liu X, Yao X.
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| Sci Rep 6:38791. doi: 10.1038/srep38791. 2016
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| 9 | GSK3A, GSK3B
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| Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.
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| Zhou J, Ahmad F, Parikh S, Hoffman NE, Rajan S, Verma VK, Song J, Yuan A, Shanmughapriya S, Guo Y, Gao E, Koch W, Woodgett JR, Madesh M, Kishore R, Lal H, Force T.
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| Circ Res 118(8):1208-22. doi: 10.1161/CIRCRESAHA.116.308544. Epub 2016 Mar 14.
2016
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| 10 | CTNNB1, GSK3B
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| Glucose deprivation triggers protein kinase C-dependent β-catenin proteasomal degradation.
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| Choi SW, Song JK, Yim YS, Yun HG, Chun KH.
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| J Biol Chem 290(15):9863-73. doi: 10.1074/jbc.M114.606756. Epub 2015 Feb 17.
2015
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| 11 | GSK3B, SLC6A5, SLC6A9
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| Glycine transporters GlyT1 and GlyT2 are differentially modulated by glycogen synthase kinase 3β.
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| Jiménez E, Núñez E, Ibáñez I, Zafra F, Aragón C, Giménez C.
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| Neuropharmacology 89:245-54. doi: 10.1016/j.neuropharm.2014.09.023. Epub 2014 Oct 6.
2015
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| 12 | AGRN, CLASP2, GSK3B, PHLDB2
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| CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles.
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| Basu S, Sladecek S, Martinez de la Peña y Valenzuela I, Akaaboune M, Smal I, Martin K, Galjart N, Brenner HR.
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| Mol Biol Cell 26(5):938-51. doi: 10.1091/mbc.E14-06-1158. Epub 2015 Jan 14.
2015
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| 13 | GPHN, GSK3B, KIF5A, NLGN2
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| GSK3 and KIF5 regulate activity-dependent sorting of gephyrin between axons and dendrites.
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| Rathgeber L, Gromova KV, Schaefer I, Breiden P, Lohr C, Kneussel M.
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| Eur J Cell Biol 94(3-4):173-8. doi: 10.1016/j.ejcb.2015.01.005.
2015
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| 14 | AKT1, GSK3B, ZNRF1
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| Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration.
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| Wakatsuki S, Furuno A, Ohshima M, Araki T.
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| J Cell Biol 211(4):881-96. doi: 10.1083/jcb.201506102. Epub 2015 Nov 16.
2015
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| 15 | DZIP1, GSK3B, RAB8A
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| GSK3β-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis.
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| Zhang B, Zhang T, Wang G, Wang G, Chi W, Jiang Q, Zhang C.
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| PLoS Biol 13(4):e1002129. doi: 10.1371/journal.pbio.1002129. eCollection 2015 Apr.
2015
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| 16 | GSK3A, GSK3B
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| Loss of glycogen synthase kinase 3 isoforms during murine oocyte growth induces offspring cardiac dysfunction.
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| Monteiro da Rocha A, Ding J, Slawny N, Wolf AM, Smith GD.
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| Biol Reprod 92(5):127. doi: 10.1095/biolreprod.115.128181. Epub 2015 Apr 1.
2015
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| 17 | GSK3A, GSK3B
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| Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleus.
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| Besing RC, Paul JR, Hablitz LM, Rogers CO, Johnson RL, Young ME, Gamble KL.
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| J Biol Rhythms 30(2):155-60. doi: 10.1177/0748730415573167. Epub 2015 Feb 27.
2015
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| 18 | GSK3A, GSK3B
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| A novel role for GSK3 in the regulation of the processes of human labour.
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| Lim R, Lappas M.
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| Reproduction 149(2):189-202. doi: 10.1530/REP-14-0493.
2015
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| 19 | GSK3B, SRF
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| SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons.
|
| Li CL, Sathyamurthy A, Oldenborg A, Tank D, Ramanan N.
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| J Neurosci 34(11):4027-42. doi: 10.1523/JNEUROSCI.4677-12.2014.
2014
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| 20 | CLASP2, GSK3B
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| Acetylcholine receptor (AChR) clustering is regulated both by glycogen synthase kinase 3β (GSK3β)-dependent phosphorylation and the level of CLIP-associated protein 2 (CLASP2) mediating the capture of microtubule plus-ends.
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| Basu S, Sladecek S, Pemble H, Wittmann T, Slotman JA, van Cappellen W, Brenner HR, Galjart N.
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| J Biol Chem 289(44):30857-67. doi: 10.1074/jbc.M114.589457. Epub 2014 Sep 17.
2014
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| 21 | GSK3B, MACF1
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| MACF1 regulates the migration of pyramidal neurons via microtubule dynamics and GSK-3 signaling.
|
| Ka M, Jung EM, Mueller U, Kim WY.
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| Dev Biol 395(1):4-18. doi: 10.1016/j.ydbio.2014.09.009. Epub 2014 Sep 16.
2014
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| 22 | GSK3A, GSK3B
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| GSK3β, but not GSK3α, inhibits the neuronal differentiation of neural progenitor cells as a downstream target of mammalian target of rapamycin complex1.
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| Ahn J, Jang J, Choi J, Lee J, Oh SH, Lee J, Yoon K, Kim S.
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| Stem Cells Dev 23(10):1121-33. doi: 10.1089/scd.2013.0397. Epub 2014 Mar 3.
2014
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| 23 | ALDOA, ALDOB, ALDOC, GSK3B
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| Aldolase positively regulates of the canonical Wnt signaling pathway.
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| Caspi M, Perry G, Skalka N, Meisel S, Firsow A, Amit M, Rosin-Arbesfeld R.
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| Mol Cancer 13:164. doi: 10.1186/1476-4598-13-164.
2014
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| 24 | GSK3B, PCDH9, SNAI1
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| Protocadherin 9 inhibits epithelial-mesenchymal transition and cell migration through activating GSK-3β in hepatocellular carcinoma.
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| Zhu P, Lv J, Yang Z, Guo L, Zhang L, Li M, Han W, Chen X, Zhuang H, Lu F.
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| Biochem Biophys Res Commun 452(3):567-74. doi: 10.1016/j.bbrc.2014.08.101. Epub 2014 Aug 27.
2014
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| 25 | GSK3B, RMDN3, TARDBP
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| ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43
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| Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho RM, Lau KF, Vizcay-Barrena G, Lin WL, Xu YF, Lewis J, Dickson DW, Petrucelli L, Mitchell JC, Shaw CE, Miller CC.
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| Nat Commun. Jun 3;5:3996. doi: 10.1038/ncomms4996 2014
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| 26 | GSK3B, KLF6
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| GSK3β phosphorylation of the KLF6 tumor suppressor promotes its transactivation of p21.
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| Lang UE, Kocabayoglu P, Cheng GZ, Ghiassi-Nejad Z, Muñoz U, Vetter D, Eckstein DA, Hannivoort RA, Walsh MJ, Friedman SL.
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| Oncogene 32(38):4557-64. doi: 10.1038/onc.2012.457. Epub 2012 Oct 22.
2013
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| 27 | GSK3B, KLF6
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| GSK3β phosphorylation of the KLF6 tumor suppressor promotes its transactivation of p21.
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| Lang UE, Kocabayoglu P, Cheng GZ, Ghiassi-Nejad Z, Muñoz U, Vetter D, Eckstein DA, Hannivoort RA, Walsh MJ, Friedman SL.
|
| Oncogene 32(38):4557-64. doi: 10.1038/onc.2012.457. Epub 2012 Oct 22.
2013
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| 28 | DIRK2, GSK3B
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| DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3β on eIF2Bε.
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| Weiss CS, Ochs MM, Hagenmueller M, Streit MR, Malekar P, Riffel JH, Buss SJ, Weiss KH, Sadoshima J, Katus HA, Hardt SE.
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| PLoS One 8(9):e70848. doi: 10.1371/journal.pone.0070848. eCollection 2013.
2013
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| 29 | GSK3B, NFE2L1
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| Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1.
|
| Biswas M, Kwong EK, Park E, Nagra P, Chan JY.
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| Exp Cell Res 319(13):1922-31. doi: 10.1016/j.yexcr.2013.04.013. Epub 2013 Apr 23.
2013
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| 30 | GSK3B, KIDINS220
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| Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3β/PP1 imbalance.
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| López-Menéndez C, Gamir-Morralla A, Jurado-Arjona J, Higuero AM, Campanero MR, Ferrer I, Hernández F, Ávila J, Díaz-Guerra M, Iglesias T.
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| Hum Mol Genet 22(3):466-82. doi: 10.1093/hmg/dds446. Epub 2012 Oct 31.
2013
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| 31 | CSF3R, FBXW7, GSK3B
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| E3 ubiquitin ligase Fbw7 negatively regulates granulocytic differentiation by targeting G-CSFR for degradation.
|
| Lochab S, Pal P, Kapoor I, Kanaujiya JK, Sanyal S, Behre G, Trivedi AK.
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| Biochim Biophys Acta 1833(12):2639-52. doi: 10.1016/j.bbamcr.2013.06.018.
2013
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| 32 | GSK3A, GSK3B
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| Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase.
|
| Maurin H, Lechat B, Dewachter I, Ris L, Louis JV, Borghgraef P, Devijver H, Jaworski T, Van Leuven F.
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| Mol Brain 6:27. doi: 10.1186/1756-6606-6-27.
2013
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| 33 | DPYSL2, GSK3A, GSK3B
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| GSK-3α/β-mediated phosphorylation of CRMP-2 regulates activity-dependent dendritic growth.
|
| Tan M, Ma S, Huang Q, Hu K, Song B, Li M.
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| J Neurochem 125(5):685-97. doi: 10.1111/jnc.12230. Epub 2013 Mar 25.
2013
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| 34 | GSK3A, GSK3B, PRKCA
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| Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets.
|
| Moore SF, van den Bosch MT, Hunter RW, Sakamoto K, Poole AW, Hers I.
|
| J Biol Chem 288(6):3918-28. doi: 10.1074/jbc.M112.429936. Epub 2012 Dec 13.
2013
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| 35 | GSK3B, MAPT, NUB1
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| NUB1 modulation of GSK3β reduces tau aggregation.
|
| Richet E, Pooler AM, Rodriguez T, Novoselov SS, Schmidtke G, Groettrup M, Hanger DP, Cheetham ME, van der Spuy J.
|
| Hum Mol Genet 21(24):5254-67. doi: 10.1093/hmg/dds376. Epub 2012 Sep 10.
2012
|
| 36 | GSK3B, KITLG
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| SCF and TLR4 ligand cooperate to augment the tumor-promoting potential of mast cells.
|
| Wei JJ, Song CW, Sun LC, Yuan Y, Li D, Yan B, Liao SJ, Zhu JH, Wang Q, Zhang GM, Feng ZH.
|
| Cancer Immunol Immunother 61(3):303-12. doi: 10.1007/s00262-011-1098-z. Epub 2011 Aug 30.
2012
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| 37 | GSK3B, NR3C1
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| Glycogen synthase kinase-3β is involved in ligand-dependent activation of transcription and cellular localization of the glucocorticoid receptor.
|
| Rubio-Patiño C, Palmeri CM, Pérez-Perarnau A, Cosialls AM, Moncunill-Massaguer C, González-Gironès DM, Pons-Hernández L, López JM, Ventura F, Gil J, Pons G, Iglesias-Serret D.
|
| Mol Endocrinol 26(9):1508-20. doi: 10.1210/me.2011-1366. Epub 2012 Jul 6.
2012
|
| 38 | GSK3A, GSK3B, KAT5, ULK1
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| GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.
|
| Lin SY, Li TY, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC.
|
| Science 336(6080):477-81. doi: 10.1126/science.1217032. Erratum in: Science. 2012 Aug 17;337(6096):799.
2012
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| 39 | EIF2AK2, GSK3B
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| PKR plays a positive role in osteoblast differentiation by regulating GSK-3β activity through a β-catenin-independent pathway.
|
| Yoshida K, Okamura H, Ochiai K, Hoshino Y, Haneji T, Yoshioka M, Hinode D, Yoshida H.
|
| Mol Cell Endocrinol 361(1-2):99-105. doi: 10.1016/j.mce.2012.03.019. Epub 2012 Apr 5.
2012
|
| 40 | AKT1, GSK3B, STYK1
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| NOK/STYK1 interacts with GSK-3β and mediates Ser9 phosphorylation through activated Akt.
|
| Li J, Wu F, Sheng F, Li YJ, Jin D, Ding X, Zhang S.
|
| FEBS Lett 586(21):3787-92. doi: 10.1016/j.febslet.2012.09.011. Epub 2012 Sep 23.
2012
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| 41 | GSK3B, KLC2, LMTK2
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| Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo.
|
| Manser C, Guillot F, Vagnoni A, Davies J, Lau KF, McLoughlin DM, De Vos KJ, Miller CC.
|
| Oncogene 31(22):2773-82. doi: 10.1038/onc.2011.437. Epub 2011 Sep 26.
2012
|
| 42 | DNAJB6, GSK3B, SPP1
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| DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin.
|
| Mitra A, Menezes ME, Pannell LK, Mulekar MS, Honkanen RE, Shevde LA, Samant RS.
|
| Oncogene 31(41):4472-83. doi: 10.1038/onc.2011.623. Epub 2012 Jan 23.
2012
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| 43 | GSK3A, GSK3B
|
| Glycogen synthase kinase 3 inhibition promotes lysosomal biogenesis and autophagic degradation of the amyloid-β precursor protein.
|
| Parr C, Carzaniga R, Gentleman SM, Van Leuven F, Walter J, Sastre M.
|
| Mol Cell Biol 32(21):4410-8. doi: 10.1128/MCB.00930-12. Epub 2012 Aug 27. Erratum in: Mol Cell Biol. 2016 Apr 1;36(7):1219.
2012
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| 44 | GSK3B, LCMT1, PPME1, PPP2CA
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| Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.
|
| Yao XQ, Li XC, Zhang XX, Yin YY, Liu B, Luo DJ, Wang Q, Wang JZ, Liu GP.
|
| FEBS Lett 586(16):2522-8. doi: 10.1016/j.febslet.2012.06.018. Epub 2012 Jun 22.
2012
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| 45 | GSK3A, GSK3B, RELA
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| GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation.
|
| Itoh S, Saito T, Hirata M, Ushita M, Ikeda T, Woodgett JR, Algül H, Schmid RM, Chung UI, Kawaguchi H.
|
| J Biol Chem 287(35):29227-36. doi: 10.1074/jbc.M112.372086. Epub 2012 Jul 3.
2012
|
| 46 | AXIN1, GSK3B, STRAP
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| Role of STRAP in regulating GSK3β function and Notch3 stabilization.
|
| Kashikar ND, Zhang W, Massion PP, Gonzalez AL, Datta PK.
|
| Cell Cycle 10(10):1639-54. Epub 2011 May 15.
2011
|
| 47 | GSK3B
|
| Inhibition of glycogen synthase kinase-3 enhances the differentiation and reduces the proliferation of adult human olfactory epithelium neural precursors.
|
| Manceur AP, Tseng M, Holowacz T, Witterick I, Weksberg R, McCurdy RD, Warsh JJ, Audet J.
|
| Exp Cell Res 317(15):2086-98. Epub 2011 Jun 25.
2011
|
| 48 | GSK3B, MAPT
|
| GSK3β is involved in the relief of mitochondria pausing in a Tau-dependent manner.
|
| Llorens-Martín M, López-Doménech G, Soriano E, Avila J.
|
| PLoS One 6(11):e27686. doi: 10.1371/journal.pone.0027686. Epub 2011 Nov 14.
2011
|
| 49 | GSK3B, RELB
|
| Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation.
|
| Neumann M, Klar S, Wilisch-Neumann A, Hollenbach E, Kavuri S, Leverkus M, Kandolf R, Brunner-Weinzierl MC, Klingel K.
|
| Oncogene 30(21):2485-92. doi: 10.1038/onc.2010.580. Epub 2011 Jan 10.
2011
|
| 50 | APC, CTNNB1, DISC1, DLG4, FZD1, GSK3B, NEUROD1, PRICKLE1, SFRP1, SYN1, WNT1, WNT3, WNT3A, WNT5A, WNT7A
|
| Emerging roles of Wnts in the adult nervous system.
|
| Inestrosa NC, Arenas E.
|
| Nat Rev Neurosci. 11(2):77-86. 2010
|
| 51 | DFNA51, GSK3B, TJP2
|
| Genomic duplication and overexpression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51.
|
| Walsh T, Pierce SB, Lenz DR, Brownstein Z, Dagan-Rosenfeld O, Shahin H, Roeb W, McCarthy S, Nord AS, Gordon CR, Ben-Neriah Z, Sebat J, Kanaan M, Lee MK, Frydman M, King MC, Avraham KB.
|
| Am J Hum Genet 87(1):101-9. Epub 2010 Jun 17.PMID: 20602916 2010
|
| 52 | GSK3A, GSK3B
|
| Glycogen Synthase Kinase 3 (GSK-3) influences epithelial barrier function by regulating Occludin, Claudin-1 and E-cadherin expression.
|
| Severson EA, Kwon M, Hilgarth RS, Parkos CA, Nusrat A.
|
| Biochem Biophys Res Commun iochem Biophys Res Commun. 2010 Jun 2. [Epub ahead of print]PMID: 20685350 2010
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| 53 | GSK3A, GSK3B
|
| GSK3 signalling in neural development.
|
| Hur EM, Zhou FQ.
|
| Nat Rev Neurosci. 11(8):539-51. 2010
|
| 54 | GSK3B, THRAP3
|
| Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.
|
| Heyd F, Lynch KW.
|
| Mol Cell 40(1):126-37.PMID: 20932480 2010
|
| 55 | GRN, GSK3B
|
| Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.
|
| Gao X, Joselin AP, Wang L, Kar A, Ray P, Bateman A, Goate AM, Wu JY.
|
| Protein Cell 1(6):552-62. doi: 10.1007/s13238-010-0067-1. Epub 2010 Jul 7.
2010
|
| 56 | DPYSL3, GSK3B
|
| GSK3 regulates mitotic chromosomal alignment through CRMP4.
|
| Ong Tone S, Dayanandan B, Fournier AE, Mandato CA.
|
| PLoS One 5(12):e14345. doi: 10.1371/journal.pone.0014345.
2010
|
| 57 | DISC1, GSK3B
|
| Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.
|
| Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai LH
|
| Cell 20;136(6):1017-31 2009
|
| 58 | BRSK1, BRSK2, CDC42, DCX, DOCK7, DPYSL2, GSK3A, GSK3B, IGF1, KIF13B, KIF2A, KLC1, LIS1, MAP1B, MAP2, MAPK8, MAPT, NIN, PAFAH1B1, SCG10, SCLIP, STK11, STMN1, STMN2, STMN3, STRADA
|
| Microtubule assembly, organization and dynamics in axons and dendrites.
|
| Conde C, Caceres A.
|
| Nat Rev Neurosci. 10(5):319-32. 2009
|
| 59 | GSK3B, MEF2D
|
| Phosphorylation of neuronal survival factor MEF2D by glycogen synthase kinase 3beta in neuronal apoptosis.
|
| Wang X, She H, Mao Z.
|
| J Biol Chem 284(47):32619-26. Epub 2009 Sep 29.PMID: 19801631 2009
|
| 60 | GSK3B, HK2
|
| Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3.
|
| Gimenez-Cassina A, Lim F, Cerrato T, Palomo GM, Diaz-Nido J.
|
| J Biol Chem 284(5):3001-11. Epub 2008 Nov 25.PMID: 19033437 2009
|
| 61 | GSK3B, HSPA5, HSPH1
|
| HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation.
|
| Meares GP, Zmijewska AA, Jope RS.
|
| Cell Signal 20(2):347-58. Epub 2007 Nov 17. 2008
|
| 62 | GSK3B, MAPK14
|
| Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.
|
| Thornton TM, Pedraza-Alva G, Deng B, Wood CD, Aronshtam A, Clements JL, Sabio G, Davis RJ, Matthews DE, Doble B, Rincon M.
|
| Science 320(5876):667-70. 2008
|
| 63 | TRAF6, GSK3B
|
| TRAF6-mediated regulation of the PI3 kinase (PI3K)-Akt-GSK3beta cascade is required for TNF-induced cell survival.
|
| Yoon K, Jung EJ, Lee SY.
|
| Biochem Biophys Res Commun 371(1):118-21. Epub 2008 Apr 11. 2008
|
| 64 | ATOH1, GSK3B
|
| Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer.
|
| Aragaki M, Tsuchiya K, Okamoto R, Yoshioka S, Nakamura T, Sakamoto N, Kanai T, Watanabe M.
|
| Biochem Biophys Res Commun 368(4):923-9. Epub 2008 Feb 12. 2008
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| 65 | LRP6, GSK3A, GSK3B, CTNNB1, AXIN1
|
| LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.
|
| Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E.
|
| Proc Natl Acad Sci U S A 105(23):8032-7. Epub 2008 May 28. 2008
|
| 66 | AURKA, AURKAIP1, GSK3B
|
| AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta.
|
| Fumoto K, Lee PC, Saya H, Kikuchi A.
|
| Oncogene 27(32):4478-87. Epub 2008 Apr 7.
2008
|
| 67 | BIRC2, DDX3X, GSK3B
|
| Identification of an antiapoptotic protein complex at death receptors.
|
| Sun M, Song L, Li Y, Zhou T, Jope RS.
|
| Cell Death Differ 15(12):1887-900. Epub 2008 Oct 10.
2008
|
| 68 | GSK3B
|
| Deletion of GSK-3-beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation.
|
| Kerkela, R.; Kockeritz, L.; MacAulay, K.; Zhou, J.; Doble, B. W.; Beahm, C.; Greytak, S.; Woulfe, K.; Trivedi, C. M.; Woodgett, J. R.; Epstein, J. A.; Force, T.; Huggins, G. S.
|
| J. Clin. Invest. 118: 3609-3618 2008
|
| 69 | E2F1, GSK3B
|
| The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation.
|
| Zhou F, Zhang L, Wang A, Song B, Gong K, Zhang L, Hu M, Zhang X, Zhao N, Gong Y.
|
| J Biol Chem. 283(21):14506-15. 2008
|
| 70 | GSK3B
|
| Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling.
|
| Guo X, Ramirez A, Waddell DS, Li Z, Liu X, Wang XF.
|
| Genes Dev. 22(1):106-20 2008
|
| 71 | GSK3B, SPAG5
|
| Glycogen synthase kinase 3beta interacts with and phosphorylates the spindle-associated protein astrin.
|
| Cheng TS, Hsiao YL, Lin CC, Yu CT, Hsu CM, Chang MS, Lee CI, Huang CY, Howng SL, Hong YR.
|
| J Biol Chem 283(4):2454-64. Epub 2007 Nov 30.
2008
|
| 72 | GSK3B, TUBGCP5
|
| GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5.
|
| Izumi N, Fumoto K, Izumi S, Kikuchi A.
|
| J Biol Chem 283(19):12981-91. Epub 2008 Mar 3.
2008
|
| 73 | ARHGAP31, GSK3A, GSK3B
|
| Glycogen synthase kinase-3 phosphorylates CdGAP at a consensus ERK 1 regulatory site.
|
| Danek EI, Tcherkezian J, Triki I, Meriane M, Lamarche-Vane N.
|
| J Biol Chem 282(6):3624-31. Epub 2006 Dec 8. 2007
|
| 74 | GSK3A, GSK3B
|
| GSK3 alpha and GSK3 beta are necessary for axon formation.
|
| Garrido JJ, Simon D, Varea O, Wandosell F.
|
| FEBS Lett 581(8):1579-86. Epub 2007 Mar 19. 2007
|
| 75 | SNAI1, GSK3B
|
| Snail1 is involved in the renal epithelial-mesenchymal transition.
|
| Yoshino J, Monkawa T, Tsuji M, Inukai M, Itoh H, Hayashi M.
|
| Biochem Biophys Res Commun 362(1):63-8. Epub 2007 Aug 3. 2007
|
| 76 | CTPS1, GSK3A, GSK3B
|
| Regulation of human cytidine triphosphate synthetase 1 by glycogen synthase kinase 3.
|
| Higgins MJ, Graves PR, Graves LM.
|
| J Biol Chem 282(40):29493-503. Epub 2007 Aug 6. 2007
|
| 77 | GSK3B
|
| Chemical rescue of cleft palate and midline defects in conditional GSK-3-beta mice.
|
| Liu, K. J.; Arron, J. R.; Stankunas, K.; Crabtree, G. R.; Longaker, M. T.
|
| Nature 446: 79-82 2007
|
| 78 | GSK3B
|
| Glycogen synthase kinase-3 is involved in the regulation of the cell cycle in cerebellar granule cells.
|
| Yeste-Velasco M, Folch J, Trullàs R, Abad MA, Enguita M, Pallàs M, Camins A.
|
| Neuropharmacology 53(2):295-307. Epub 2007 May 26.PMID: 17612578 2007
|
| 79 | GSK3B, MAP3K11
|
| Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3.
|
| Mishra R, Barthwal MK, Sondarva G, Rana B, Wong L, Chatterjee M, Woodgett JR, Rana A.
|
| J Biol Chem 282(42):30393-405. Epub 2007 Aug 21.PMID: 17711861 2007
|
| 80 | WNT1, AXIN2, SNAI1, GSK3B
|
| A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells.
|
| Yook JI, Li XY, Ota I, Hu C, Kim HS, Kim NH, Cha SY, Ryu JK, Choi YJ, Kim J, Fearon ER, Weiss SJ.
|
| Nat Cell Biol 8(12):1398-406. Epub 2006 Oct 29. 2006
|
| 81 | EN1,GSK3B
|
| Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway.
|
| Bachar-Dahan L, Goltzmann J, Yaniv A, Gazit A.
|
| Mol Biol Cell 17(6):2572-80. Epub 2006 Mar 29. 2006
|
| 82 | GSK3A, GSK3B
|
| GSK-3 is activated by the tyrosine kinase Pyk2 during LPA1-mediated neurite retraction.
|
| Sayas CL, Ariaens A, Ponsioen B, Moolenaar WH.
|
| Mol Biol Cell 17(4):1834-44. Epub 2006 Feb 1. 2006
|
| 83 | BICD1, GSK3B
|
| GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.
|
| Fumoto K, Hoogenraad CC, Kikuchi A.
|
| EMBO J 25(24):5670-82. Epub 2006 Nov 30.
2006
|
| 84 | GSK3B
|
| Association between glycogen synthase kinase-3beta genetic polymorphism and late-onset Alzheimer's disease.
|
| Mateo I, Infante J, Llorca J, Rodríguez E, Berciano J, Combarros O.
|
| Dement Geriatr Cogn Disord. 21(4):228-32. 2006
|
| 85 | GSK3B, PRUNE
|
| Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions.
|
| Kobayashi T, Hino S, Oue N, Asahara T, Zollo M, Yasui W, Kikuchi A.
|
| Mol Cell Biol 26(3):898-911.PMID: 16428445 2006
|
| 86 | GSK3B, NTF3, DPSYL2
|
| GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.
|
| Yoshimura T, Kawano Y, Arimura N, Kawabata S, Kikuchi A, Kaibuchi K.
|
| Cell 120(1):137-49. 2005
|
| 87 | GSK3B
|
| Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease.
|
| Hye A, Kerr F, Archer N, Foy C, Poppe M, Brown R, Hamilton G, Powell J, Anderton B, Lovestone S.
|
| Neurosci Lett 373(1):1-4. 2005
|
| 88 | BTRC, CREBBP, CSRP2, FKBP8, GAS1, GSK3B, HHAT, HHIP, IFT88, KIF27, KIF3A, KIF7, RAB23, SHH, STIL, STK36, SUFU, VTN
|
| Hedgehog signaling and congenital malformations.
|
| Nieuwenhuis E, Hui CC.
|
| Clin Genet 67(3):193-208. 2005
|
| 89 | EPM2A, GYS1, GYS2, NHLRC1, EPM2B, GSK3A, GSK3B
|
| Novel glycogen synthase kinase 3 and ubiquitination pathways in progressive myoclonus epilepsy.
|
| Lohi H, Ianzano L, Zhao XC, Chan EM, Turnbull J, Scherer SW, Ackerley CA, Minassian BA.
|
| Hum Mol Genet 14(18):2727-36. Epub 2005 Aug 22. 2005
|
| 90 | CABYR, GSK3B
|
| Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.
|
| Hsu HC, Lee YL, Cheng TS, Howng SL, Chang LK, Lu PJ, Hong YR.
|
| Biochem Biophys Res Commun 329(3):1108-17. 2005
|
| 91 | FRAT2, GSK3B
|
| FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation.
|
| Stoothoff WH, Cho JH, McDonald RP, Johnson GV.
|
| J Biol Chem 280(1):270-6. Epub 2004 Nov 1.
2005
|
| 92 | AKT1, GSK3B
|
| Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.
|
| Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA.
|
| Nat Genet 36(2):131-7. Epub 2004 Jan 25. 2004
|
| 93 | NIN, GSK3B, C14orf166
|
| A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors.
|
| Howng SL, Hsu HC, Cheng TS, Lee YL, Chang LK, Lu PJ, Hong YR.
|
| FEBS Lett 566(1-3):162-8. 2004
|
| 94 | GSK3B
|
| A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression.
|
| Benedetti F, Serretti A, Colombo C, Lorenzi C, Tubazio V, Smeraldi E.
|
| Neurosci Lett. 368(2):123-6. 2004
|
| 95 | GSK3B
|
| Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.
|
| Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, Hung MC.
|
| Nat Cell Biol. 6(10):931-40. 2004
|
| 96 | GSK3B, NOTCH2
|
| Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways.
|
| Espinosa L, Inglés-Esteve J, Aguilera C, Bigas A.
|
| J Biol Chem. 278(34):32227-35. 2003
|
| 97 | GSK3A, GSK3B
|
| Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
|
| Fang X, Yu S, Tanyi JL, Lu Y, Woodgett JR, Mills GB.
|
| Mol Cell Biol 22(7):2099-110. 2002
|
| 98 | FRAT1, FRAT2, GSK3B
|
| Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2.
|
| Freemantle SJ, Portland HB, Ewings K, Dmitrovsky F, DiPetrillo K, Spinella MJ, Dmitrovsky E.
|
| Gene 291(1-2):17-27. 2002
|
| 99 | AKAP11, GSK3B
|
| A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.
|
| Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A.
|
| J Biol Chem 277(40):36955-61. Epub 2002 Jul 29. 2002
|
| 100 | GSK3B
|
| Glycogen synthase kinase-3beta modulates notch signaling and stability.
|
| Foltz DR, Santiago MC, Berechid BE, Nye JS.
|
| Curr Biol. 12(12):1006-11. 2002
|
| 101 | GSK3B
|
| Focal adhesion kinase (FAK) regulates insulin-stimulated glycogen synthesis in hepatocytes.
|
| Huang D, Cheung AT, Parsons JT, Bryer-Ash M.
|
| J Biol Chem 277(20):18151-60 2002
|
| 102 | GSK3B
|
| Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction.
|
| Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S.
|
| Biochem Biophys Res Commun. 293(4):1191-6. 2002
|
| 103 | GSK3B
|
| Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage.
|
| Watcharasit P, Bijur GN, Zmijewski JW, Song L, Zmijewska A, Chen X, Johnson GV, Jope RS.
|
| Proc. Nat. Acad. Sci. 99(12):7951-5 2002
|
| 104 | GSK3B
|
| Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3beta.
|
| Mukai F, Ishiguro K, Sano Y, Fujita SC.
|
| J Neurochem. 81(5):1073-83. 2002
|
| 105 | GSK3A, GSK3B
|
| A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation.
|
| Frame S, Cohen P, Biondi RM.
|
| Mol Cell 7(6):1321-7. 2001
|
| 106 | GSK3B
|
| Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice.
|
| Lucas JJ, Hernandez F, Gomez-Ramos P, Moran MA, Hen R, Avila J.
|
| EMBO J 20(1-2):27-39. 2001
|
| 107 | GSK3B
|
| Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3 beta.
|
| Bijur GN, Jope RS.
|
| J Biol Chem 276(40):37436-42. 2001
|
| 108 | GSK3B, PTK2B
|
| Glycogen synthase kinase 3beta is tyrosine phosphorylated by PYK2.
|
| Hartigan JA, Xiong WC, Johnson GV.
|
| Biochem Biophys Res Commun 284(2):485-9. 2001
|
| 109 | GSK3B, NIN
|
| Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta.
|
| Hong YR, Chen CH, Chang JH, Wang S, Sy WD, Chou CK, Howng SL.
|
| Biochim Biophys Acta 1492(2-3):513-6. 2000
|
| 110 | GSK3A, GSK3B
|
| Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation.
|
| Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR.
|
| Nature 406(6791):86-90. 2000
|
| 111 | GSK3B
|
| Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter.
|
| Lau KF, et al.
|
| Genomics 60(2):121-8 1999
|
| 112 | APC, AXIN1, CTNNB1, GSK3B
|
| Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level.
|
| Nakamura T, Hamada F, Ishidate T, Anai K, Kawahara K, Toyoshima K, Akiyama T.
|
| Genes Cells 3 : 395-403. 1998
|
| 113 | AXIN1, CTNNB1, GSK3B
|
| Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.
|
| Ikeda S, et al.
|
| EMBO J 17 : 1371-1384. 1998
|
| 114 | GSK3A, GSK3B
|
| Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes.
|
| Shaw PC, Davies AF, Lau KF, Garcia-Barcelo M, Waye MM, Lovestone S, Miller CC, Anderton BH.
|
| Genome 41 : 720-727. 1998
|
| 115 | DNM1L, GSK3B
|
| Human dynamin-like protein interacts with the glycogen synthase kinase 3beta.
|
| Hong YR, Chen CH, Cheng DS, Howng SL, Chow CC.
|
| Biochem Biophys Res Commun 249(3):697-703. 1998
|
| 116 | GSK3A, GSK3B
|
| Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.
|
| Pap M, Cooper GM.
|
| J Biol Chem 273(32):19929-32. 1998
|
| 117 | GSK3B
|
| Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin.
|
| Li Y, Bharti A, Chen D, Gong J, Kufe D.
|
| Mol Cell Biol. 18(12):7216-24 1998
|
| 118 | GSK3A, GSK3B
|
| Expression analysis of glycogen synthase kinase-3 in human tissues.
|
| Lau KF, Miller CC, Anderton BH, Shaw PC.
|
| J Pept Res. J Pept Res. 1998
|
| 119 | GSK3A, GSK3B
|
| Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3alpha and beta isoforms in patients with NIDDM.
|
| Hansen L, Arden KC, Rasmussen SB, Viars CS, Vestergaard H, Hansen T, Moller AM, Woodgett JR, Pedersen O.
|
| Diabetologia 40(8):940-6. 1997
|
| 120 | APC, GSK3B
|
| Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly.
|
| Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P.
|
| Science 272 : 1023-1026. 1996
|
| 121 | GSK3B
|
| A molecular mechanism for the effect of lithium on development.
|
| Klein PS, Melton DA.
|
| Proc Natl Acad Sci U S A. 93(16):8455-9. 1996
|
| 122 | GSK3A, GSK3B
|
| Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos.
|
| He X, Saint-Jeannet JP, Woodgett JR, Varmus HE, Dawid IB.
|
| Nature 374(6523):617-22. 1995
|
| 123 | GSK3B
|
| Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.
|
| Wang QM, et al.
|
| J Biol Chem 269(20):14566-74 1994
|
| 124 | GSK3B
|
| Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments.
|
| Ishiguro K, et al.
|
| FEBS Lett 325 : 167-172. 1993
|
| 125 | GSK3B
|
| Wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate.
|
| Siegfried E, et al.
|
| Cell 71 : 1167-1179. 1992
|
| 126 | GSK3B
|
| Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes.
|
| Goode N, Hughes K, Woodgett JR, Parker PJ.
|
| J Biol Chem. 267(24):16878-82. 1992
|