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FLASH GENE

Symbol

GSK3B

contributors: mct - updated : 24-11-2022

HGNC name	glycogen synthase kinase 3 beta
HGNC id	4617

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in Alzeihmer's disease and might be a useful diagnostic marker constitutional       loss of function enhances the differentiation and reduces the proliferation of adult olfactory epithelium neural precursors

Susceptibility

Variant & Polymorphism SNP	single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression and influences onset of illness in patients affected by bipolar disorder
	association between Glycogen Synthase Kinase-3beta genetic polymorphism and Late-Onset Alzheimer's Disease

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative   modulating GSK3B or similar signaling events may provide therapeutic benefits for FTDU17 (with GRN mutations) miscelleaneous urinary chronic kidney disease GSK3B−SNAI1 axis may be a suitable target for the treatment of chronic kidney diseases cancer     targeting GSK3B and DDX3X may be a useful strategy for promoting death receptor-induced apoptosis neurology neurodegenerative alzheimer use of inhibitors of this kinase for therapies in AD and related dementias are already available

ANIMAL & CELL MODELS

	overexpression of Gsk3b in conditional transgenic mice results in hyperphosphorylation of tau and neurodegeneration
	Gsk3b-deficient mice embryos show severe liver degeneration, a phenotype consistent with excessive tummor nercrosis factor
	Xenopus dominant negative mutants induced dorsal differentiation
	alterations of GSK3 profoundly affect neuronal morphology in culture
	knockdown of both GSK3B markedly reduced axon growth in dissociated cultures
	Homozygous null mice display cleft palate, incomplete fusion of the ribs at the midline and bifid sternum as well as delayed sternal ossification
	Gsk3b knockin mice (Tph2) show a markedly reduced brain serotonin (5-HT) neurotransmission production and behavioral abnormalities in tests assessing 5-HT-mediated emotional states
	Gsk3b-/- mice exhibit hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation
	concomitant loss of Gsk3a and Gsk3b in the oocyte significantly increased neonatal death rate due to congestive heart failur