| protein
| APC-beta-catenin complex |
|
facilitating NFKB activation |
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PTK2B protein tyrosine kinase 2 beta (PTK2B) |
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v-akt murine thymoma viral oncogene homolog 1 (AKT1) (AKT1/GSK3B signaling required for axons elongation and branching ) |
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phosphorylates tau protein |
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tubulin polymerization promoting protein (TPPP) |
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phosphorylated by AKT1 and ILK1 |
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ninein (NIN) (phosphorylating NIN) |
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calcium binding tyrosine-(Y)-phosphorylation regulated (CABYR) |
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mucin 1, cell surface associated (MUC1) |
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prune homolog (Drosophila) (PRUNE) |
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NF-kappaB |
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A kinase (PRKA) anchor protein 11 (AKAP11) |
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human dynamin-like protein IV (HdynIV) |
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Axin and requently rearranged in advanced T-cell lymphomas 1 and 2 (Frat1, Frat2) |
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DF3/MUC1 carcinoma-associated antigen and beta-catenin |
|
modulates Notch1 signaling |
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binds and phosphorylates Notch2 |
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p53 after DNA damage  |
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E2F transcription factor 1 (E2F1) |
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SMAD family member 3 (SMAD3) |
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FRAT2 significantly increased GSK3B-mediated phosphorylation of MAPT at a primed epitope while not significantly affecting the phosphorylation of unprimed sites |
|
snail homolog 1 (Drosophila), SNAI1 |
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Bicaudal-D, BICD |
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interacting with HK2 (mitochondrial HK2 is a promoter of neuronal survival under the regulation of GSK3B) |
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interacting with MAP3K11 (cell death induced by GSK3B was mediated by MAP3K11 in a manner dependent on its phosphorylation of the specific residues within the C-terminal domain by GSK3B) |
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interacting with HSPH1 and HSPA5, a key component of the unfolded protein response (promotes ER stress-induced caspase-3 activation) |
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interacts with and phosphorylates the spindle-associated protein SPAG5, resulting in targeting SPAG5 to the spindle microtubules and kinetochores |
|
Disrupted in Schizophrenia 1, DISC1 |
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interacting with TJP2 (TJP2 overexpression results in changes in GSK3B phosphorylation and apoptosis-related gene expression and these changes increase the susceptibility of inner ear cells to apoptosis) |
|
controlling expression of the AJC (Apical Junctional Complex) proteins OCLN, CLDN1 and CDH1 as well as regulation of downstream signaling events essential for maintaining epithelial barrier and homeostatic functions |
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is a key physiological substrate of GSK3B in regulating chromosomal alignment and mitotic progression through its effect on spindle microtubule |
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important role of PGRN in neurite outgrowth and involvement of GSK3B in mediating PGRN activity |
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GSK3B is a crucial regulator of RELB degradation, stressing the relevant linkage between the NFKB system and GSK3B |
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binding of GSK3B with a novel scaffold protein, STRAP, through its WD40 domains |
|
KITLG and TLR4 ligand cooperated to induce phosphorylation of GSK3B at Tyr216 by simultaneous activation of ERK and MAPK14 pathways |
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LMTK2 regulates a known pathway that controls phosphorylation of kinesin-1 light chain-2 (KLC2) by glycogen synthase kinase-3& |
|
946; (GSK3B) |
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GSK3B activity regulates mitochondrial axonal trafficking largely in a MAPT-dependent manner |
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DNAJB6 binds HSPA8 and causes dephosphorylation of GSK3B at Ser 9 by recruiting protein phosphatase, PPP2CA |
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EIF2AK2 positively regulates the differentiation of osteoblasts by mediating GSK3B activity through a CTNNB1-independent pathway |
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redundant functions of GSK3A and GSK3B through phosphorylation of RELA at Thr-254 play a crucial role in early stages of chondrocyte differentiation |
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GSK3B regulates NR3C1 response by genomic and nongenomic mechanisms |
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GSK3B can inhibit PPP2CA by increasing the inhibitory L309-demethylation involving upregulation of PPME1 and inhibition of LCMT1 |
|
NUB1 interacted with both MAPT and GSK3B to disrupt their interaction, and abolished recruitment of GSK3B to MAPT inclusions |
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directly phosphorylates KLF6, which augments its induction of CDKN1A and resultant growth suppression) |
|
PRKCA and AKT1 modulate platelet function by phosphorylating and inhibiting GSK3A/GSK3B, thereby relieving the negative effect of GSK3A/GSK3B on thrombin-mediated platelet activation |
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GSK3B interacts with NFE2L1 and phosphorylates the CDC4 phosphodegron domain (CPD) in NFE2L1 |
|
FBXW7 together with GSK3B negatively regulates CSF3R expression and its downstream signaling |
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interaction of GSK3B and its priming kinase DYRK2 regulate the activity of EIF2B in cardiac myocytes |
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phosphorylation and activation of SRF by GSK3B is critical for SRF-dependent axon growth in mammalian central neurons) |
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TARDBP leads to activation of GSK3B and GSK3B regulates the VAPB-RMDN3 interaction |
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ALDOC, ALDOA and ALDOB activate Wnt signaling in a GSK3B-dependent mechanism |
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PCDH9 is a novel regulator of EMT by increasing the activity of GSK3B and inhibiting SNAI1 |
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MACF1 interacts with and mediates GSK3B signaling in developing neurons |
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GSK3B is important for stabilizing and/or controlling the expression of functional SLC6A5, SLC6A9 on the neural cell surface |
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transport system, organized by AGRN through PI3 kinase, GSK3B, CLASP2, and PHLDB2, for precise delivery of CHRNA1 vesicles from the subsynaptic nuclei to the overlying synaptic membrane |
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molecular mechanism by which glucose deprivation can induce the GSK3B-independent protein degradation of CTNNB1, leading to autophagy |
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GSK3B regulates the sorting of GPHN and NLGN2 complexes in a KIF5A-dependent manner |
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ZNRF1 promotes Wallerian degeneration by degrading AKT1 to induce GSK3B activation |
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GIMAP5 is essential for the inactivation of GSK3B following T cell activation |
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STIP1 acts as a scaffold promoting the interaction between KDM1A and GSK3B |
|
BCL2L14, PIEZO2,HOXB8, KIF18A, DLK1, TNFSF14, CASQ2 genes may play an important role in the GSK3B-mediated osteoblast apoptosis process |
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PIWIL2 suppressed GSK3B induced phosphorylation and ubiquitination of CTNNB1, and thus increased CTNNB1 accumulation in the nucleus |
|
MCL1 stability is regulated by the kinase GSK3B and the E3 ubiquitin ligase HUWE1 in regulating AMBRA1-mediated mitophagy |
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phosphorylation of USP27X by GSK3B maintains the stability and oncogenic functions of CBX2 |
