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| alterations of GSK3 profoundly affect neuronal morphology in culture | |
knockdown of both GSK3B markedly reduced axon growth in dissociated cultures |
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concomitant loss of Gsk3a and Gsk3b in the oocyte significantly increased neonatal death rate due to congestive heart failure secondary to ventricular hyperplasia  |
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dominant-negative GSK-3 Xenopus mutants induced dorsal differentiation, whereas wild-type GSK-3 induced ventralization |
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disruption of the Gsk3a gene in testis results in normal spermatogenesis, but mature sperm present a reduced motility, rendering male mice infertile |