| 1 | GSK3A
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| Isoform-specific GSK3A activity is negatively correlated with human sperm motility.
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| Freitas MJ, Silva JV, Brothag C, Regadas-Correia B, Fardilha M, Vijayaraghavan S.
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| Mol Hum Reprod ol Hum Reprod. 2019 Mar 2. pii: gaz009. doi: 10.1093/molehr/gaz009. [Epub ahead of print]
2019
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| 2 | GSK3A, RABEP2
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| Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3).
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| Logie L, Van Aalten L, Knebel A, Force T, Hastie CJ, MacLauchlan H, Campbell DG, Gourlay R, Prescott A, Davidson J, Fuller W, Sutherland C.
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| Sci Rep 7(1):17682. doi: 10.1038/s41598-017-17087-6.
2017
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| 3 | CREB1, GSK3A
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| GSK-3α Is a Novel Target of CREB and CREB-GSK-3α Signaling Participates in Cell Viability in Lung Cancer.
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| Park SA, Lee JW, Herbst RS, Koo JS.
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| PLoS One 11(4):e0153075. doi: 10.1371/journal.pone.0153075. eCollection 2016.
2016
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| 4 | GSK3A, GSK3B
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| Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.
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| Zhou J, Ahmad F, Parikh S, Hoffman NE, Rajan S, Verma VK, Song J, Yuan A, Shanmughapriya S, Guo Y, Gao E, Koch W, Woodgett JR, Madesh M, Kishore R, Lal H, Force T.
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| Circ Res 118(8):1208-22. doi: 10.1161/CIRCRESAHA.116.308544. Epub 2016 Mar 14.
2016
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| 5 | DSP, GSK3A, PRMT1
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| GSK3- and PRMT-1-dependent modifications of desmoplakin control desmoplakin-cytoskeleton dynamics.
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| Albrecht LV, Zhang L, Shabanowitz J, Purevjav E, Towbin JA, Hunt DF, Green KJ.
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| J Cell Biol 208(5):597-612. doi: 10.1083/jcb.201406020.
2015
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| 6 | GSK3A, GSK3B
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| Loss of glycogen synthase kinase 3 isoforms during murine oocyte growth induces offspring cardiac dysfunction.
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| Monteiro da Rocha A, Ding J, Slawny N, Wolf AM, Smith GD.
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| Biol Reprod 92(5):127. doi: 10.1095/biolreprod.115.128181. Epub 2015 Apr 1.
2015
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| 7 | GSK3A, GSK3B
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| Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleus.
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| Besing RC, Paul JR, Hablitz LM, Rogers CO, Johnson RL, Young ME, Gamble KL.
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| J Biol Rhythms 30(2):155-60. doi: 10.1177/0748730415573167. Epub 2015 Feb 27.
2015
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| 8 | GSK3A, GSK3B
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| A novel role for GSK3 in the regulation of the processes of human labour.
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| Lim R, Lappas M.
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| Reproduction 149(2):189-202. doi: 10.1530/REP-14-0493.
2015
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| 9 | GSK3A, GSK3B
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| GSK3β, but not GSK3α, inhibits the neuronal differentiation of neural progenitor cells as a downstream target of mammalian target of rapamycin complex1.
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| Ahn J, Jang J, Choi J, Lee J, Oh SH, Lee J, Yoon K, Kim S.
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| Stem Cells Dev 23(10):1121-33. doi: 10.1089/scd.2013.0397. Epub 2014 Mar 3.
2014
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| 10 | GSK3A
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| Expression and regulation of glycogen synthase kinase 3 in human neutrophils.
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| Giambelluca MS, Cloutier N, Rollet-Labelle E, Boilard E, Pouliot M.
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| Int J Biochem Cell Biol 45(11):2660-5. doi: 10.1016/j.biocel.2013.09.001. Epub 2013 Sep 10.
2013
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| 11 | GSK3A, GSK3B
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| Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase.
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| Maurin H, Lechat B, Dewachter I, Ris L, Louis JV, Borghgraef P, Devijver H, Jaworski T, Van Leuven F.
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| Mol Brain 6:27. doi: 10.1186/1756-6606-6-27.
2013
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| 12 | GSK3A, SP7
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| Glycogen synthase kinase 3 alpha phosphorylates and regulates the osteogenic activity of Osterix.
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| Li H, Jeong HM, Choi YH, Lee SH, Jeong HG, Jeong TC, Lee KY.
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| Biochem Biophys Res Commun 434(3):653-8. doi: 10.1016/j.bbrc.2013.03.137. Epub 2013 Apr 11.
2013
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| 13 | DPYSL2, GSK3A, GSK3B
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| GSK-3α/β-mediated phosphorylation of CRMP-2 regulates activity-dependent dendritic growth.
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| Tan M, Ma S, Huang Q, Hu K, Song B, Li M.
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| J Neurochem 125(5):685-97. doi: 10.1111/jnc.12230. Epub 2013 Mar 25.
2013
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| 14 | GSK3A, GSK3B, PRKCA
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| Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets.
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| Moore SF, van den Bosch MT, Hunter RW, Sakamoto K, Poole AW, Hers I.
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| J Biol Chem 288(6):3918-28. doi: 10.1074/jbc.M112.429936. Epub 2012 Dec 13.
2013
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| 15 | GSK3A, GSK3B, KAT5, ULK1
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| GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.
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| Lin SY, Li TY, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC.
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| Science 336(6080):477-81. doi: 10.1126/science.1217032. Erratum in: Science. 2012 Aug 17;337(6096):799.
2012
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| 16 | GSK3A, GSK3B
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| Glycogen synthase kinase 3 inhibition promotes lysosomal biogenesis and autophagic degradation of the amyloid-β precursor protein.
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| Parr C, Carzaniga R, Gentleman SM, Van Leuven F, Walter J, Sastre M.
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| Mol Cell Biol 32(21):4410-8. doi: 10.1128/MCB.00930-12. Epub 2012 Aug 27. Erratum in: Mol Cell Biol. 2016 Apr 1;36(7):1219.
2012
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| 17 | GSK3A, GSK3B, RELA
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| GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation.
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| Itoh S, Saito T, Hirata M, Ushita M, Ikeda T, Woodgett JR, Algül H, Schmid RM, Chung UI, Kawaguchi H.
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| J Biol Chem 287(35):29227-36. doi: 10.1074/jbc.M112.372086. Epub 2012 Jul 3.
2012
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| 18 | CLASP1, GSK3A
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| GSK3 controls axon growth via CLASP-mediated regulation of growth cone microtubules.
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| Hur EM, Saijilafu, Lee BD, Kim SJ, Xu WL, Zhou FQ.
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| Genes Dev 25(18):1968-81. doi: 10.1101/gad.17015911.
2011
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| 19 | GSK3A, GSK3B
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| Glycogen Synthase Kinase 3 (GSK-3) influences epithelial barrier function by regulating Occludin, Claudin-1 and E-cadherin expression.
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| Severson EA, Kwon M, Hilgarth RS, Parkos CA, Nusrat A.
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| Biochem Biophys Res Commun iochem Biophys Res Commun. 2010 Jun 2. [Epub ahead of print]PMID: 20685350 2010
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| 20 | GSK3A, GSK3B
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| GSK3 signalling in neural development.
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| Hur EM, Zhou FQ.
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| Nat Rev Neurosci. 11(8):539-51. 2010
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| 21 | BRSK1, BRSK2, CDC42, DCX, DOCK7, DPYSL2, GSK3A, GSK3B, IGF1, KIF13B, KIF2A, KLC1, LIS1, MAP1B, MAP2, MAPK8, MAPT, NIN, PAFAH1B1, SCG10, SCLIP, STK11, STMN1, STMN2, STMN3, STRADA
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| Microtubule assembly, organization and dynamics in axons and dendrites.
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| Conde C, Caceres A.
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| Nat Rev Neurosci. 10(5):319-32. 2009
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| 22 | LRP6, GSK3A, GSK3B, CTNNB1, AXIN1
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| LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.
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| Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E.
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| Proc Natl Acad Sci U S A 105(23):8032-7. Epub 2008 May 28. 2008
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| 23 | GSK3A
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| Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy.
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| Wang, Z.; Smith, K. S.; Murphy, M.; Piloto, O.; Somervaille, T. C. P.; Cleary, M. L.
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| Nature 455: 1205-1209 2008
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| 24 | ARHGAP31, GSK3A, GSK3B
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| Glycogen synthase kinase-3 phosphorylates CdGAP at a consensus ERK 1 regulatory site.
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| Danek EI, Tcherkezian J, Triki I, Meriane M, Lamarche-Vane N.
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| J Biol Chem 282(6):3624-31. Epub 2006 Dec 8. 2007
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| 25 | GSK3A, GSK3B
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| GSK3 alpha and GSK3 beta are necessary for axon formation.
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| Garrido JJ, Simon D, Varea O, Wandosell F.
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| FEBS Lett 581(8):1579-86. Epub 2007 Mar 19. 2007
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| 26 | CTPS1, GSK3A, GSK3B
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| Regulation of human cytidine triphosphate synthetase 1 by glycogen synthase kinase 3.
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| Higgins MJ, Graves PR, Graves LM.
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| J Biol Chem 282(40):29493-503. Epub 2007 Aug 6. 2007
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| 27 | GSK3A
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| Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells.
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| Ciaraldi TP, Nikoulina SE, Bandukwala RA, Carter L, Henry RR.
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| Endocrinology. 148(9):4393-9. 2007
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| 28 | GSK3A, GSK3B
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| GSK-3 is activated by the tyrosine kinase Pyk2 during LPA1-mediated neurite retraction.
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| Sayas CL, Ariaens A, Ponsioen B, Moolenaar WH.
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| Mol Biol Cell 17(4):1834-44. Epub 2006 Feb 1. 2006
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| 29 | GSK3A
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| Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.
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| Maurer, U.; Charvet, C.; Wagman, A. S.; Dejardin, E.; Green, D. R.
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| Mol Cell. 21: 749-760 2006
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| 30 | EPM2A, GYS1, GYS2, NHLRC1, EPM2B, GSK3A, GSK3B
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| Novel glycogen synthase kinase 3 and ubiquitination pathways in progressive myoclonus epilepsy.
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| Lohi H, Ianzano L, Zhao XC, Chan EM, Turnbull J, Scherer SW, Ackerley CA, Minassian BA.
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| Hum Mol Genet 14(18):2727-36. Epub 2005 Aug 22. 2005
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| 31 | HNRPA3, SELENBP1, GSK3A, BTG1, HLA-DRB1
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| Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia.
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| Glatt SJ, Everall IP, Kremen WS, Corbeil J, Sasik R, Khanlou N, Han M, Liew CC, Tsuang MT.
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| Proc Natl Acad Sci U S A 102(43):15533-8. Epub 2005 Oct 13. 2005
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| 32 | GSK3A
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| Role for glycogen synthase kinase-3 in NK cell cytotoxicity and X-linked lymphoproliferative disease.
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| Aoukaty, A.; Tan, R.
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| J. Immun. 174: 4551-4558 2005
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| 33 | GSK3A, HDAC1
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| GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity.
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| Viatour P, Dejardin E, Warnier M, Lair F, Claudio E, Bureau F, Marine JC, Merville MP, Maurer U, Green D, Piette J, Siebenlist U, Bours V, Chariot A.
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| Mol Cell. 16(1):35-45. 2004
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| 34 | GSK3A
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| Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth.
|
| Mazor M, Kawano Y, Zhu H, Waxman J, Kypta RM.
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| Oncogene. 23(47):7882-92. 2004
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| 35 | GSK3A
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| GSK-3-alpha regulates production of Alzheimer's disease amyloid-beta peptides.
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| Phiel, C. J.; Wilson, C. A.; Lee, V. M.-Y.; Klein, P. S.
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| Nature 423: 435-439 2003
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| 36 | GSK3A, GSK3B
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| Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
|
| Fang X, Yu S, Tanyi JL, Lu Y, Woodgett JR, Mills GB.
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| Mol Cell Biol 22(7):2099-110. 2002
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| 37 | GSK3A, GSK3B
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| A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation.
|
| Frame S, Cohen P, Biondi RM.
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| Mol Cell 7(6):1321-7. 2001
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| 38 | GSK3A, GSK3B
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| Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation.
|
| Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR.
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| Nature 406(6791):86-90. 2000
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| 39 | GSK3A
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| Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.
|
| Fang X, Yu SX, Lu Y, Bast RC Jr, Woodgett JR, Mills GB.
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| Proc Natl Acad Sci U S A 97(22):11960-5. 2000
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| 40 | GSK3A, GSK3B
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| Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes.
|
| Shaw PC, Davies AF, Lau KF, Garcia-Barcelo M, Waye MM, Lovestone S, Miller CC, Anderton BH.
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| Genome 41 : 720-727. 1998
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| 41 | FRAT2, GSK3A
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| GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis.
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| Yost C, Farr GH 3rd, Pierce SB, Ferkey DM, Chen MM, Kimelman D.
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| Cell 93(6):1031-41. 1998
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| 42 | GSK3A, GSK3B
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| Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.
|
| Pap M, Cooper GM.
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| J Biol Chem 273(32):19929-32. 1998
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| 43 | GSK3A, GSK3B
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| Expression analysis of glycogen synthase kinase-3 in human tissues.
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| Lau KF, Miller CC, Anderton BH, Shaw PC.
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| J Pept Res. J Pept Res. 1998
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| 44 | GSK3A
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| Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin.
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| Welsh GI, Miller CM, Loughlin AJ, Price NT, Proud CG.
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| FEBS Lett. 421(2):125-30. 1998
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| 45 | GSK3A, GSK3B
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| Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3alpha and beta isoforms in patients with NIDDM.
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| Hansen L, Arden KC, Rasmussen SB, Viars CS, Vestergaard H, Hansen T, Moller AM, Woodgett JR, Pedersen O.
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| Diabetologia 40(8):940-6. 1997
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| 46 | GSK3A, GSK3B
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| Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos.
|
| He X, Saint-Jeannet JP, Woodgett JR, Varmus HE, Dawid IB.
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| Nature 374(6523):617-22. 1995
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| 47 | GSK3A
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| Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
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| Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA.
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| Nature. 378(6559):785-9. 1995
|
| 48 | GSK3A
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| Molecular cloning and expression of glycogen synthase kinase-3/factor A.
|
| Woodgett JR.
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| EMBO J 9 : 2431-2438. 1990
|