| basic FUNCTION
| glycogen synthase kinase, dual-specificity protein-kinase |
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an important regulator of muscle insulin action  |
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regulator of glycogen synthesis in skeletal muscle through Tyr (activating) or Ser/Thr (inactivating) phosphorylation |
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key downstream target of PI3-kinase/AKT survival sognaling pathway and involved in regulation of apoptosis |
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regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1 |
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regulates microtubule growth and stability, phosphorylating many microtubule associated proteins such as tau, MAP1b and CRMP-2 or APC |
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playing an essential role for axon outgrowth |
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implicated in the control of several regulatory proteins including glycogen synthase |
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plays a role in the WNT and PI3K signaling pathways |
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a downstream effector of PI3K that phosphorylates proteins involved in regulating microtubule dynamics and microtubule-based transport |
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role in NK cell cytotoxicity and X-linked lymphoproliferative disease |
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regulates production of Alzheimer's disease amyloid-beta peptides |
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role in control neurogenesis, neuronal polarization and axon growth and guidance during brain development |
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negatively regulates the expression of the adherens junction protein CDH1, thereby influencing barrier function and inhibiting epithelial–mesenchymal transition (EMT) |
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controls axon growth via CLASP1-mediated regulation of growth cone microtubules |
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new role of GSK3A, GSK3B as regulators of lysosomal biogenesis which could have important consequences in neurodegenerative diseases, such as AD |
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GSK3A is a multifunctional serine/threonine protein kinase that plays a role in the Wnt signaling pathways and is implicated in the control of several regulatory proteins and transcription factors |
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GSK3A contributed to the neuronal architecture of the hippocampal CA1 sub-region that is most vulnerable in Alzheimer disease |
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GSK3A, GSK3B were regulated independently, but that they acted on the same physiological functions in learning and memory, in mobility and in behavior |
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GSK3A is the main isoform expressed in neutrophils and many different pathways can converge to inhibit GSK3A activity via Ser21-phosphorylation |
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GSK3B, but not GSK3A, negatively controls the neuronal differentiation of progenitor cells and GSK3B may act downstream of the mammalian target of rapamycin complex1 signaling pathway |
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cardiac myocyte GSK3A, GSK3B3 is required to maintain normal cardiac homeostasis, and its loss is incompatible with life because of cell cycle dysregulation that ultimately results in a severe fatal dilated cardiomyopathy |
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isoform-specific GSK3A activity is negatively correlated with human sperm motility |
