| Symbol
| HOXB8
| contributors: mct - updated : 17-04-2020
|
| HGNC name
| homeo box B8
|
| HGNC id
| 5119
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
| |
increased expression of the gene is associated with colorectal cancer | | tumoral
|
|
| --over
|
| |
in the tumor tissue of Glioblastoma multiforme (GBM) patients, and a strong positive correlation between the expression level and pathological grading of tumors and a negative correlation between the expression level and the overall survival rat | | tumoral
|
|
| --over
|
|
in osteosarcoma tissues and cell lines  | | tumoral
|
|
| --other
|
| |
HOXB8 expression is associated with shorter survival in metastatic ovarian serous carcinoma | |
Variant & Polymorphism
| 
| |
Candidate gene
| Marker
| HOXB8 may be an independent prognostic factor in Colorectal cancer | Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | bone | | |
| may represent a novel therapeutic target for the treatment of Osteosarcoma |
| | |
|
| Hoxb8 knocked-out mice exhibit an excessive pathologic grooming behavior, that is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania | |
adult mice with an Lmx1b loss restricted to Hoxb8 neurons have nociception defects and disrupted organization of primary sensory afferent axons innervating the dorsal horn |