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FLASH GENE
Symbol HOXB8 contributors: mct - updated : 17-04-2020
HGNC name homeo box B8
HGNC id 5119
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
increased expression of the gene is associated with colorectal cancer
tumoral     --over  
in the tumor tissue of Glioblastoma multiforme (GBM) patients, and a strong positive correlation between the expression level and pathological grading of tumors and a negative correlation between the expression level and the overall survival rat
tumoral     --over  
in osteosarcoma tissues and cell lines
tumoral     --other  
HOXB8 expression is associated with shorter survival in metastatic ovarian serous carcinoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • HOXB8 may be an independent prognostic factor in Colorectal cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbone 
    may represent a novel therapeutic target for the treatment of Osteosarcoma
    ANIMAL & CELL MODELS
  • Hoxb8 knocked-out mice exhibit an excessive pathologic grooming behavior, that is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania
  • adult mice with an Lmx1b loss restricted to Hoxb8 neurons have nociception defects and disrupted organization of primary sensory afferent axons innervating the dorsal horn