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FLASH GENE
Symbol PRKAG2 contributors: mct/npt - updated : 30-11-2009
HGNC name protein kinase, AMP-activated, gamma 2 non-catalytic subunit
HGNC id 9386
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four cystathionine-beta-synthase (CBS) forming a stable globular domain
    • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies ortholog to rattus Prkag2 (98.5pc)
    ortholog to murine Prkag2 (93.8pc)
    intraspecies homolog to PRKAG1
    Homologene
    FAMILY
  • 5'-AMP-activated protein kinase gamma subunit family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • being responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase
  • regulating cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase
  • involved in the pathogenesis of Alzheimer disease
  • stimulates energy production via glucose and lipid metabolism, whereas it inhibits energy consuming functions, such as protein and cholesterol synthesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    fatty acid biosynthesis ; cholesterol biosynthesis
    a component
  • heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by cAMP
    ASSOCIATED DISORDERS
    corresponding disease(s) WPW , GSDH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS