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FLASH GENE

Symbol

PRKAG2

contributors: mct/npt - updated : 30-11-2009

HGNC name	protein kinase, AMP-activated, gamma 2 non-catalytic subunit
HGNC id	9386

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine small intestine     moderately   intestine large intestine colon   moderately Endocrine adrenal gland       moderately   parathyroid       moderately Lymphoid/Immune thymus       moderately Reproductive female system placenta     predominantly   female system ovary     highly   male system testis       Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four cystathionine-beta-synthase (CBS) forming a stable globular domain

mono polymer

heteromer , trimer

HOMOLOGY

interspecies	ortholog to rattus Prkag2 (98.5pc)
	ortholog to murine Prkag2 (93.8pc)

intraspecies

homolog to PRKAG1

Homologene

FAMILY

5'-AMP-activated protein kinase gamma subunit family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION	being responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase
	regulating cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase
	involved in the pathogenesis of Alzheimer disease
	stimulates energy production via glucose and lipid metabolism, whereas it inhibits energy consuming functions, such as protein and cholesterol synthesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

fatty acid biosynthesis ; cholesterol biosynthesis

a component

heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

cAMP

ASSOCIATED DISORDERS

corresponding disease(s)

WPW , GSDH

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS