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FLASH GENE
Symbol CASP5 contributors: mct/npt/shn - updated : 05-04-2012
HGNC name caspase 5, apoptosis-related cysteine peptidase
HGNC id 1506
Location 11q22.2-q22.3      Physical location : 104.864.966 - 104.893.895
Synonym name
  • caspase 5, apoptosis-related cysteine protease
  • interleukin 1 beta-convertase, related cell death 3
  • ICH-3 protease
  • protease ICH-3
  • ICE(rel)-III
  • caspase-5 subunit p20
  • caspase-5 subunit p10
  • CASP-5
  • caspase-5
  • TY protease
  • protease TY
  • apoptosis-related cysteine protease
  • Synonym symbol(s) ICER3, ICE(rel)III, ICH-3, MGC141966
    EC.number 3.4.22.36, 3.4.22.58
    DNA
    TYPE functioning gene
    STRUCTURE 28.93 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D11S4951 - D11S1886 - CASP5 - D11S2000 - D11S1781 - qter
    Physical map
    LOC390248 11 similar to matrix metalloproteinase 1 precursor MMP10 11q22.2-q22.3 matrix metalloproteinase 10 (stromelysin 2) MMP1 11q22.2-q22.3 matrix metalloproteinase 1 (interstitial collagenase) LOC120321 11q22.2 similar to casein kinase 1, alpha 1 MMP3 11q22.2-q22.3 matrix metalloproteinase 3 (stromelysin 1, progelatinase) MMP12 11q22.3 matrix metalloproteinase 12 (macrophage elastase) MMP13 11q22.2-q22.3 matrix metalloproteinase 13 (collagenase 3) MGC2714 11q22.2 hypothetical protein MGC2714 DNCH2 11q21-q22.1 dynein, cytoplasmic, heavy polypeptide 2 SCDGF-B CASP12P1 11q22.3 caspase 12 pseudogene 1 CASP4 11q22.2-q22.3 caspase 4, apoptosis-related cysteine protease CASP5 11q22.2-q22.3 caspase 5, apoptosis-related cysteine protease CASP1 11q22.2-q22.3 caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase) COP  clathrin-ordered protein ICEBERG 11q21-q22 ICEBERG caspase-1 inhibitor OR2AL1P 11q23.3 olfactory receptor, family 2, subfamily AL, member 1 pseudogene GRIA4 11q22.3 glutamate receptor, ionotrophic, AMPA 4 KIAA1826 11q22 KIAA1826 protein KBTBD3 11q22.3 kelch repeat and BTB (POZ) domain containing 3 AASDHPPT 11q22 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase GUCY1A2 11q21-q22 guanylate cyclase 1, soluble, alpha 2 LOC341230 11q23.1 similar to argininosuccinate synthetase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 1023 - 292 - -
    8 splicing 1165
    9 splicing 1275 - 376 - -
    7 splicing 913
    10 splicing 1488 - 447 - -
    10 splicing 1449 - 434 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   lowly Homo sapiens
    Endocrinepancreas   lowly Homo sapiens
    Reproductivefemale systemplacenta  moderately Homo sapiens
    Respiratorylung   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal (Fas-associating protein with DEATH domain) FADD-like death effector domain
  • a conserved QACXG pentapeptide active site motif
  • an (A) 10 repeat within its coding region
  • mono polymer heteromer , tetramer
    isoforms Precursor precursor producing two subunits,large (20kDa) and small (10kDa) that dimerize
    HOMOLOGY
    interspecies ortholog to CASP5, pan troglodytes
    Homologene
    FAMILY
  • caspase family of cysteinyl-aspartate specific proteases
  • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,cytosolic
    text stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli
    basic FUNCTION
  • caspase 5, cysteine containing aspartate-specific protease, inducing apoptosis in fibroblast, lacking convertase activity
  • potentially involved in procytokine activation
  • may be a suppressor gene of highly metastatic potential in lung cancer
  • having pro-apoptotic and pro-inflammatory activities
  • may work predominantly in concert with caspase-1 in modulating human retinal pigment epithelial inflammatory responses (
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cleaves and activates MAX after FXS mediated dephosphorylation (
  • cleaves Periphilin (
  • NACHT, LRR and PYD containing protein 1, NALP1 (
  • cell & other
    REGULATION
    Other regulated by IFNG and lipopolysaccharide
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mutated in lung cancer with highly metastatic potential in lung cancer