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FLASH GENE

Symbol

CASP5

contributors: mct/npt/shn - updated : 05-04-2015

HGNC name	caspase 5, apoptosis-related cysteine peptidase
HGNC id	1506

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q22.3      Physical location : 104.864.966 - 104.893.895
Synonym name	caspase 5, apoptosis-related cysteine protease
	interleukin 1 beta-convertase, related cell death 3
	ICH-3 protease
	protease ICH-3
	ICE(rel)-III
	caspase-5 subunit p20
	caspase-5 subunit p10
	CASP-5
	caspase-5
	TY protease
	protease TY
	apoptosis-related cysteine protease
Synonym symbol(s)	ICER3, ICE(rel)III, ICH-3, MGC141966
EC.number	3.4.22.36, 3.4.22.58

DNA

TYPE	functioning gene
STRUCTURE	29.67 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D11S4951 - D11S1886 - CASP5 - D11S2000 - D11S1781 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001136110 (transcript variant c) 8 splicing 1028 NP_001129582 - 292 - 2018 29715460 NR_024239 (transcript variant e) 8 splicing 1165 NM_001136109 (transcript variant b) 9 splicing 1275 NP_001129581 - 376 - 2018 29715460 NR_036562 (transcript variant g) 7 splicing 913 NM_001136112 (transcript variant f) 10 splicing 1488 NP_001129584 - 447 - 2018 29715460 NM_004347 (transcript variant a) 10 splicing 1449 NP_004338 - 434 - 2018 29715460

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       lowly Homo sapiens Endocrine pancreas       lowly Homo sapiens Reproductive female system placenta     moderately Homo sapiens Respiratory lung       highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal (Fas-associating protein with DEATH domain) FADD-like death effector domain
	a conserved QACXG pentapeptide active site motif
	an (A) 10 repeat within its coding region

mono polymer

heteromer , tetramer

isoforms

Precursor

precursor producing two subunits,large (20kDa) and small (10kDa) that dimerize

HOMOLOGY

interspecies

ortholog to CASP5, pan troglodytes

Homologene

FAMILY

caspase family of cysteinyl-aspartate specific proteases

CATEGORY

enzyme , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,cytosolic
text	stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli

basic FUNCTION	caspase 5, cysteine containing aspartate-specific protease, inducing apoptosis in fibroblast, lacking convertase activity
	potentially involved in procytokine activation
	may be a suppressor gene of highly metastatic potential in lung cancer
	having pro-apoptotic and pro-inflammatory activities
	changes of CASP2 and CASP5 activities could be indicative of their involvement in the cervical malignancy mechanisms
	CASP5 and the inflammasome may have an important role in the inflammatory response in psoriasis
	concerted endoproteolytic activity of CASP5 and CASP10
	may work predominantly in concert with caspase-1 in modulating human retinal pigment epithelial inflammatory responses (
	both CASP4 and CASP5 are functionally important for appropriate responses to intracellular Gram-negative bacteria
	mainly participates in cell growth, apoptosis and other physiological process

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	cleaves and activates MAX after FXS mediated dephosphorylation (
	cleaves Periphilin (
	NACHT, LRR and PYD containing protein 1, NALP1 (
	CASP4 and caspase-5 mediate IL1A and IL1B release from human monocytes after lipopolysaccharide (LPS) stimulation
	CASP4, CASP5, and SCAF11 directly bind endotoxin (LOS/LPS) and can be activated in the absence of any co-factors
	IL17A promoted CASP5 function via facilitation of the NLRP1-inflammasome

cell & other

REGULATION

Other

regulated by IFNG and lipopolysaccharide

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in glioblastoma multiforme constitutional     --over   can promote the angiogenesis significantly, possibly by inhibiting the ANGPT1/TEK pathway and promoting VEGFA pathway constitutional     --over   in lesional psoriatic skin

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mutated in lung cancer with highly metastatic potential in lung cancer