basic FUNCTION
| involved in acute leukemia |
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central role for the MLL2 complex in the growth of ESR1-positive cancer cells (Mo 2006) |
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transcriptional activator inducing the transcription of target genes by covalent histone modification and involved in the regulation of adhesion-related cytoskeletal events, which might affect cell growth and survival (Issaeva 2007) |
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controls most of the promoter-specific chromatin modification, H3K4me3, during oogenesis and early development |
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contributes to the epigenetic reprogramming that takes place before fertilization |
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specialized biological role in macrophage function and antimicrobial response |
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its reexpression was sufficient to reinstate an active MAGOHB promoter |
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mediates hippocampal histone 3 lysine 4 di- and trimethylation and is a critical player for memory formation |
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histone H3K4 methyltransferase that is a component of the genetic regulation necessary for glucose homeostasis, resulting in a specific disease pattern linking chromatin modification with causes and progression of type 2 diabetes |
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required for H3K4 trimethylation on bivalent promoters in embryonic stem cell |
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KMT2C, KMT2D are broadly required for controlling MAFA and MAFB transactivation during development and postnatally |
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KMT2C/KMT2D and H3K27 acetyltransferases CREBBP/EP300 are major enhancer epigenomic writers |